Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oviedo, Aldo Delgado, Alfonso Querejeta, Enrique |
| Description | Country affiliation: Mexico Author Affiliation: Oviedo A ( Department of Physiology and Pharmacology, National Polytechnic Institute School of Medicine, (ESM-IPN), México D.F., Mexico.) |
| Abstract | The reciprocal connections between the globus pallidus (GP) and other basal ganglia (BG) nuclei indicate that the GP plays a significant role in controlling the neuronal activity of the entire BG; in turn, the activity of GP neurons is controlled by several major inputs that involve the striatum. Here, we determined the relative contributions of the selective (chemical) or massive (electrical) activation of the striatal GABAergic transmission to the GP spiking activity. In vivo extracelullar single-unit recordings were performed in the GP of ketamine-anesthetized rats. Both chemical and electrical stimulation of the striatum caused a significant GP spike rate reduction; however, chemical stimulation of the striatum produced a complete firing arrest on most GP neurons, something not seen with electrical stimulation. In addition, chemical stimulation of the striatum with NMDA evoked a significant long-lasting post-inhibitory spike rate increase, an effect that was not seen under glutamate infusion or electrical stimulation. Furthermore, the selective intrapallidal blockade of AMPA/kainate glutamate receptors facilitates the inhibitory effect of intrastriatal electrical stimulation. Our results suggest a differential effect of electrical or chemical stimulation of the striatum on the spiking activity of GP neurons, which involves the activation of intrapallidal AMPA/kainate receptors and striatal en passant fibers. |
| File Format | HTM / HTML |
| ISSN | 01680102 |
| Issue Number | 4 |
| Volume Number | 62 |
| e-ISSN | 18728111 |
| Journal | Neuroscience Research |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-12-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Corpus Striatum Physiology Globus Pallidus Cytology Neural Inhibition Neurons Action Potentials Drug Effects Animals Biophysics Electric Stimulation Methods Excitatory Amino Acid Agents Pharmacology Glutamic Acid Male N-methylaspartate Neural Pathways Quinoxalines Rats Rats, Wistar Stimulation, Chemical Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Medicine |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|