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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Watanabe, Satoru Matsuo, Hirotaka Kobayashi, Yasushi Satoh, Yasushi Fujita, Masanori Nakayama, Akiyoshi Aizawa, Yoshifusa Shinomiya, Nariyoshi Suzuki, Shinya |
| Description | Country affiliation: Japan Author Affiliation: Watanabe S ( Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa, Saitama 359-8513, Japan.) |
| Abstract | The neurotoxicity of carbon monoxide (CO) poisoning is a significant clinical problem, but its mechanisms remain unclear. Previous studies of CO-exposed rats showed spatial memory disturbances and degradation of myelin basic protein (MBP) in the brain; however, regional localization of the degradation was not analyzed. In the present study, we histologically determined the foci of CO effects in the hippocampus. Wistar rats were exposed to CO for 60min (1000ppm for 40min+3000ppm for 20min) and returned into room air. For histological evaluation, the animals were sacrificed 90min, 1, 7 and 14 days after CO exposure and the brain tissue was analyzed with hematoxylin-eosin (HE), Nissl and Gallyas myelin staining as well as immunohistochemistry for MBP and phosphorylated or nonphosphorylated neurofilament. No histological changes were observed on HE, Nissl or Gallyas staining. In contrast, we detected MBP reduction at 90min after CO exposure in the dentate gyrus and CA3, and the recovery of MBP was observed after 14 days. The immunoreactivity of neurofilament also changed after CO exposure. Nevertheless, water maze test showed no significant effects of CO exposure on spatial memory. Our findings demonstrate that CO poisoning causes transient degradation of MBP and axonal injury in the hippocampus even though the animals showed no neurological disturbances. |
| File Format | HTM / HTML |
| ISSN | 01680102 |
| Issue Number | 3 |
| Volume Number | 68 |
| e-ISSN | 18728111 |
| Journal | Neuroscience Research |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Carbon Monoxide Poisoning Pathology Carbon Monoxide Administration & Dosage Hippocampus Drug Effects Myelin Basic Protein Metabolism Neurons Animals Blotting, Western Immunohistochemistry Maze Learning Rats Rats, Wistar Statistics, Nonparametric Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Medicine |
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