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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Arun, Peethambaran Abu-Taleb, Rania Valiyaveettil, Manojkumar Wang, Ying Long, Joseph B. Nambiar, Madhusoodana P. |
| Description | Country affiliation: United States Author Affiliation: Arun P ( Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA. peethambaran.arun@amedd.army.mil) |
| Abstract | Blast-induced traumatic brain injury (TBI) and subsequent neurobehavioral deficits are major disabilities suffered by the military and civilian population worldwide. Rigorous scientific research is underway to understand the mechanism of blast TBI and thereby develop effective therapies for protection and treatment. By using an in vitro shock tube model of blast TBI with SH-SY5Y human neuroblastoma cells, we have demonstrated that blast exposure leads to neurobiological changes in an overpressure and time dependent manner. Paradoxically, repeated blast exposures resulted in less neuronal injury compared to single blast exposure and suggested a potential neuroprotective mechanism involving released cyclophilin A (CPA). In the present study, we demonstrate accumulation of CPA in the culture medium after repeated blast exposures supporting the notion of extracellular CPA mediated neuroprotection. Post-exposure treatment of the cells with purified recombinant CPA caused significant protection against blast-induced neuronal injury. Furthermore, repeated blast exposure was associated with phosphorylation of the proteins ERK1/2 and Bad suggesting a potential mechanism of neuroprotection by extracellular CPA and may aid in the development of targeted therapies for protection against blast-induced TBI. |
| File Format | HTM / HTML |
| ISSN | 01680102 |
| Issue Number | 1-2 |
| Volume Number | 76 |
| e-ISSN | 18728111 |
| Journal | Neuroscience Research |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Blast Injuries Metabolism Brain Injuries Cyclophilin A Neurons Pathology Blotting, Western Cell Line Pharmacology Humans Neuroprotective Agents Journal Article Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Medicine |
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