NDLI: Branching out: mechanisms of dendritic arborization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jan, Yuh-Nung Jan, Lily Yeh
Description	Country affiliation: United States Author Affiliation: Jan YN ( Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA. YuhNung.Jan@ucsf.edu)
Abstract	Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.
File Format	HTM / HTML
ISSN	1471003X
e-ISSN	14710048
DOI	10.1038/nrn2836
Journal	Nature Reviews Neuroscience
Issue Number	5
Volume Number	11
Language	English
Publisher	Nature Publishing Group
Publisher Date	2010-05-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Neurology Dendrites Physiology Animals Axons Ultrastructure Models, Neurological Morphogenesis Neurons Signal Transduction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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