NDLI: Replication licensing and cancer--a fatal entanglement?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Blow, J. Julian Gillespie, Peter J.
Description	Country affiliation: United kingdom Author Affiliation: Blow JJ ( Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, DD1 5EH, UK. j.j.blow@dundee.ac.uk)
Abstract	Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
File Format	HTM / HTML
ISSN	1474175X
e-ISSN	14741768
DOI	10.1038/nrc2500
Journal	Nature Reviews Cancer
Issue Number	10
Volume Number	8
Language	English
Publisher	Nature Publishing Group
Publisher Date	2008-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Cell Cycle Proteins Metabolism Cell Transformation, Neoplastic Dna Replication Neoplasms Nuclear Proteins Animals Dna Damage Mice Genetics Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Replication licensing and cancer--a fatal entanglement?