NDLI: Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

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Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Plantman, Stefan Patarroyo, Manuel Fried, Kaj Domogatskaya, Anna Tryggvason, Karl Hammarberg, Henrik Cullheim, Staffan
Description	Country affiliation: Sweden Author Affiliation: Plantman S ( Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. stefan.plantman@ki.se)
Abstract	A prerequisite for axon regeneration is the interaction between the growth cone and the extracellular matrix (ECM). Laminins are prominent constituents of ECM throughout the body, known to support axon growth in vitro and in vivo. The regenerative capacity of adult neurons is greatly diminished compared to embryonic or early postnatal neurons. Since most lesions in the nervous system occur in the adult, we have examined neurite outgrowth from adult mouse DRG neurons on four laminin isoforms (laminin-1/LM-111, laminin-2/LM-211, laminin-8/LM-411 and laminin-10/LM-511) in vitro. The growth on laminin-1 and -10 was trophic factor-independent and superior to the one on laminin-2 and -8, where growth was very poor in the absence of neurotrophins. Among other ECM proteins, laminins were by far the most active molecules. Using function-blocking antibodies to laminin-binding integrins, we identified non-overlapping functions of integrins alpha3beta1, alpha7beta1 and alpha6beta1 on different laminin isoforms, in that alpha3beta1 and alpha7beta1 integrins appeared to be specific receptors for both laminin-1 and-2, whereas integrin alpha6beta1 was a receptor for laminin-8 and-10. Lastly, by use of immunohistochemistry, expression of subunits of laminin-1, -2, -8 and -10 in sensory organs in the human epidermis could be demonstrated, supporting an important role for these laminins in relation to primary sensory axons.
File Format	HTM / HTML
ISSN	10447431
Issue Number	1
Volume Number	39
e-ISSN	10959327
Journal	Molecular and Cellular Neuroscience
Language	English
Publisher	Elsevier
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Molecular Biology Discipline Neurology Ganglia, Spinal Cytology Integrin Alpha3beta1 Metabolism Integrin Alpha6beta1 Integrins Laminin Neurites Protein Isoforms Animals Cell Adhesion Physiology Extracellular Matrix Chemistry Humans Genetics Mice Nerve Regeneration Neurons Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Cellular and Molecular Neuroscience

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