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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aleksenko, Svetlana S. Shmykov, Alexei Y. Oszwaldowski, Slawomir Timerbaev, Andrei R. |
| Description | Country affiliation: RUSSIA Author Affiliation: Aleksenko SS ( Institute of Chemistry, Saratov State University, Astrakhanskaya Str. 83, 410012, Saratov, Russia.) |
| Abstract | Metal-based nanoscale particles possess unique optoelectronic or magnetic properties that make them highly promising as imaging agents in cancer therapy research. The fate of nanoparticles in vivo and particularly, the delivery to tumours are closely related to their interactions with plasma proteins. Furthermore, proteins can be used to modify the nanoparticle surface in order to facilitate active targeting to tumours. Therefore, there is an ongoing need for new and more capable analytical methodologies to characterize the protein-nanoparticle binding. Due to the small-sample volume requirement, high degree of resolution and, most importantly, mild, species-friendly separation conditions, capillary electrophoresis (CE) is gaining increasing popularity in the analysis of protein-nanoparticle interaction. This perspective article highlights the potential of CE in studying reactions associated with protein-mediated transformations of nanoparticles, with the focus on quantum dots, gold and iron oxide nanoparticles. Different ways by which CE can be applied to such monitoring are summarized and critically assessed using a representative coverage of recent publications. |
| File Format | HTM / HTML |
| ISSN | 17565901 |
| Issue Number | 11 |
| Volume Number | 4 |
| e-ISSN | 1756591X |
| Journal | Metallomics |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2012-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Drug Delivery Systems Instrumentation Methods Electrophoresis, Capillary Metal Nanoparticles Chemistry Proteins Metabolism Animals Cattle Gold Humans Iron Protein Binding Quantum Dots Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics |
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