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Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate , zinc sulfate and quantum dots

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Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate , zinc sulfate and quantum dots

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tang, Song Allagadda, Vinay Chibli, Hicham Nadeau, Jay L. Mayer, Gregory D.
Description	Country affiliation: United States Author Affiliation: Tang S ( The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA. greg.mayer@ttu.edu.)
Abstract	Recent advances in the ability to manufacture and manipulate materials at the nanometer scale have led to increased production and use of many types of nanoparticles . Quantum dots (QDs) are small, fluorescent nanoparticles composed of a core of semiconductor material (e.g. cadmium selenide , zinc sulfide ) and shells or dopants of other elements. Particle core composition, size, shell, and surface chemistry have all been found to influence toxicity in cells. The aim of this study was to compare the toxicities of ionic cadmium (Cd) and zinc (Zn) and Cd- and Zn-containing QDs in zebrafish liver cells (ZFL). As expected, $Cd^{2+}$ was more toxic than $Zn^{2+},$ and the general trend of $IC_{50}-24$ h values of QDs was determined to be CdTe < CdSe/ZnS or InP/ZnS, suggesting that ZnS-shelled CdSe/ZnS QDs were more cytocompatible than bare core CdTe crystals. Smaller QDs showed greater toxicity than larger QDs. Isolated mRNA from these exposures was used to measure the expression of metal response genes including metallothionein (MT), metal response element-binding transcription factor (MTF-1), divalent metal transporter (DMT-1), zrt and irt like protein (ZIP-1) and the zinc transporter, ZnT-1. CdTe exposure induced expression of these genes in a dose dependent manner similar to that of $CdSO_{4}$ exposure. However, CdSe/ZnS and InP/ZnS altered gene expression of metal homeostasis genes in a manner different from that of the corresponding Cd or Zn salts. This implies that ZnS shells reduce QD toxicity attributed to the release of $Cd^{2+},$ but do not eliminate toxic effects caused by the nanoparticles themselves.
File Format	HTM / HTML
ISSN	17565901
Issue Number	10
Volume Number	5
e-ISSN	1756591X
Journal	Metallomics
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Cadmium Compounds Toxicity Gene Expression Regulation Drug Effects Hepatocytes Metabolism Metals Quantum Dots Sulfates Zebrafish Genetics Zinc Sulfate Animals Cadmium Cell Death Cell Survival Cytology Inhibitory Concentration 50 Zebrafish Proteins Comparative Study Journal Article Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate , zinc sulfate and quantum dots

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Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate , zinc sulfate and quantum dots