NDLI: Oxygen and oxidative stress in bronchopulmonary dysplasia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Saugstad, Ola Didrik
Description	Country affiliation: Norway Author Affiliation: Saugstad OD ( Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Norway. odsaugstad@rr-research.no)
Abstract	AIMS: to summarize present knowledge regarding the relation between oxidative stress and development of bronchopulmonary dysplasia (BPD). METHODS: relevant literature searched at Pubmed and other sources. RESULTS: Oxidative stress is generated in a number of conditions and by a number of causes such as inflammation and hyperoxia. Ontogenic aspects are discussed. Oxidative stress as physiological regulators, its relation to transcription factors and inflammation is summarized. The role of oxygen and antioxidant therapy and newborn resuscitation for development and prevention of BPD as well as new therapeutic modes especially the use of growth factors, gene therapy and stem cells, are briefly discussed. CONCLUSION: oxidative stress and BPD are associated. A better understanding of this association is necessary in order to reduce the severity and the incidence of the condition.
File Format	HTM / HTML
ISSN	03005577
Issue Number	6
Volume Number	38
e-ISSN	16193997
Journal	Journal of Perinatal Medicine
Language	English
Publisher	Walter De Gruyter
Publisher Date	2010-11-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Perinatology Bronchopulmonary Dysplasia Metabolism Oxidative Stress Physiology Oxygen Antioxidants Therapeutic Use Therapy Humans Hyperoxia Infant, Newborn Infant, Premature Transcription Factors Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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