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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rajesh, Rajaian Pushpabai |
| Description | Country affiliation: India Author Affiliation: Rajesh RP ( Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.) |
| Abstract | The venom of Conus figulinus, a vermivorous cone snail, found in the south east coast of India, has been studied in an effort to identify novel peptide toxins. The amino acid sequences of seven peptides have been established using de novo mass spectrometric based sequencing methods. Among these, three peptides belong to the M-Superfamily conotoxins, namely, Fi3a, Fi3b, and Fi3c, and one that belongs to the T-Superfamily, namely, Fi5a. The other three peptides are contryphans, namely, contryphans fib, fic, and fid. Of these Fi3b, Fi3c, Fi5a, and contryphan fib are novel and are reported for the first time from venom of C. figulinus. The details of the sequencing methods and the relationship of these peptides with other 'M'-Superfamily conotoxins from the fish hunting and mollusk hunting clades are discussed. These novel peptides could serve as a lead compounds for the development of neuropharmacologically important drugs. |
| File Format | HTM / HTML |
| ISSN | 10752617 |
| Issue Number | 1 |
| Volume Number | 21 |
| e-ISSN | 10991387 |
| Journal | Journal of Peptide Science |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Conotoxins Chemistry Conus Snail Peptides, Cyclic Amino Acid Sequence Animals Isolation & Purification Cystine Molecular Sequence Data Sequence Analysis, Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Structural Biology Medicine Drug Discovery Biochemistry Molecular Biology Pharmacology Molecular Medicine |
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