NDLI: Synthetic antimicrobial ß-peptide in dual-treatment with fluconazole or ketoconazole enhances the in vitro inhibition of planktonic and biofilm Candida albicans.

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Synthetic antimicrobial ß-peptide in dual-treatment with fluconazole or ketoconazole enhances the in vitro inhibition of planktonic and biofilm Candida albicans.

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Synthetic antimicrobial ß-peptide in dual-treatment with fluconazole or ketoconazole enhances the in vitro inhibition of planktonic and biofilm Candida albicans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mora-Navarro, Camilo Caraballo-León, Jean Torres-Lugo, Madeline Ortiz-Bermúdez, Patricia
Description	Country affiliation: Puerto Rico Author Affiliation: Mora-Navarro C ( Department of Chemical Engineering, University of Puerto Rico, Mayagüez Campus, Mayagüez, 00680, Puerto Rico.); Caraballo-León J ( Department of Chemical Engineering, University of Puerto Rico, Mayagüez Campus, Mayagüez, 00680, Puerto Rico.); Torres-Lugo M ( Department of Chemical Engineering, University of Puerto Rico, Mayagüez Campus, Mayagüez, 00680, Puerto Rico.); Ortiz-Bermúdez P ( Department of Chemical Engineering, University of Puerto Rico, Mayagüez Campus, Mayagüez, 00680, Puerto Rico.)
Abstract	Fungal infections are a pressing concern for human health worldwide, particularly for immunocompromised individuals. Current challenges such as the elevated toxicity of common antifungal drugs and the emerging resistance towards these could be overcome by multidrug therapy. Natural antimicrobial peptides, AMPs, in combination with other antifungal agents are a promising avenue to address the prevailing challenges. However, they possess limited biostability and susceptibility to proteases, which has significantly hampered their development as antifungal therapies. ß-peptides are synthetic materials designed to mimic AMPs while allowing high tunability and increased biostability. In this work, we report for the first time the inhibition achieved in Candida albicans when treated with a mixture of a ß-peptide model and fluconazole or ketoconazole. This combination treatment enhanced the biological activity of these azoles in planktonic and biofilm Candida, and also in a fluconazole-resistant strain. Furthermore, the in vitro cytotoxicity of the dual treatment was evaluated towards the human hepatoma cell line, HepG2, a widely used model derived from liver tissue, which is primarily affected by azoles. Analyses based on the LA-based method and the mass-action law principle, using a microtiter checkerboard approach, revealed synergism of the combination treatment in the inhibition of planktonic C. albicans. The dual treatment proved to be fungicidal at 48 and 72 h. Interestingly, it was also found that the viability of HepG2 was not significantly affected by the dual treatments. Finally, a remarkable enhancement in the inhibition of the highly azole-resistant biofilms and fluconazole resistant C. albicans strain was obtained.
File Format	HTM / HTML
ISSN	10752617
Issue Number	12
Volume Number	21
e-ISSN	10991387
Journal	Journal of Peptide Science
Language	English
Publisher	Wiley
Publisher Date	2015-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Antifungal Agents Pharmacology Antimicrobial Cationic Peptides Candida Albicans Drug Effects Fluconazole Ketoconazole Biofilms Physiology Cell Proliferation Cell Survival Drug Resistance, Fungal Drug Synergism Hep G2 Cells Humans In Vitro Techniques Plankton Journal Article Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Structural Biology Medicine Drug Discovery Biochemistry Molecular Biology Pharmacology Molecular Medicine

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Synthetic antimicrobial ß-peptide in dual-treatment with fluconazole or ketoconazole enhances the in vitro inhibition of planktonic and biofilm Candida albicans.

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