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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ozyurt, Kemal Celik, Ahmet Sayarlioglu, Mehmet Colgecen, Emine Inci, Rahime Karakas, Tuba Kelles, Mehmet Cetin, Gozde Y. |
| Description | Country affiliation: Turkey Author Affiliation: Ozyurt K ( Dermatology Clinic, Kayseri Education and Research Hospital, Kayseri, Turkey.) |
| Abstract | BACKGROUND: All aspects of aetiopathogenesis of recurrent aphthous stomatitis (RAS) have not been elucidated. RAS and Behçet's disease (BD) have clinical and immunological characteristics in common. Although T17 cytokines and alpha-enolase have been shown to play effective roles in BD and many other autoinflammatory diseases recently, their roles in RAS have not been studied extensively. In the present study, we investigated levels of several Th1, Th2 and Th17 pathways related cytokines and alpha-enolase to elucidate pathogenesis of RAS and to obtain data about possible treatment alternatives for the condition. METHODS: Serum interleukin-1, interleukin-13, interleukin-17, interleukin-18, interferon gamma and alpha-enolase levels in 24 patients with RAS, 30 patients with BD and 20 healthy controls were measured. RESULTS: Serum interleukin-1, interleukin-13, interleukin-17, interleukin-18, interferon gamma and alpha-enolase levels were higher in patients with RAS and patients with BD than in healthy controls (P < 0.005). CONCLUSION: Like Th1 and Th2 cells, Th17 cells were found to be effective in pathogenesis of RAS. In addition, alpha-enolase, the levels of which were high, may play an important role in etio-pathogenesis of RAS. Further studies to be designed in the light of these findings are required to shed light on pathogenesis and treatment of the condition. |
| File Format | HTM / HTML |
| ISSN | 09042512 |
| Issue Number | 9 |
| Volume Number | 43 |
| e-ISSN | 16000714 |
| Journal | Journal of Oral Pathology & Medicine |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-10-01 |
| Publisher Place | Denmark |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Dentistry Discipline Pathology Interleukins Blood Phosphopyruvate Hydratase Stomatitis, Aphthous Th1 Cells Immunology Th17 Cells Th2 Cells Adult Behcet Syndrome Female Humans Interferon-gamma Interleukin-1 Interleukin-13 Interleukin-17 Interleukin-18 Male Middle Aged Recurrence Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Oral Surgery Periodontics Cancer Research Pathology and Forensic Medicine |
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