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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schmidt, Megan E. Varga, Steven M. |
| Description | Country affiliation: United States Author Affiliation: Schmidt ME ( Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA.); Varga SM ( Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA. steven-varga@uiowa.edu.) |
| Abstract | Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection. |
| File Format | HTM / HTML |
| ISSN | 12258873 |
| Issue Number | 3 |
| Volume Number | 55 |
| e-ISSN | 19763794 |
| Journal | Journal of Microbiology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2017-03-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Immunomodulation Respiratory Syncytial Virus Infections Immunology Respiratory Syncytial Virus, Human Pathogenicity Viral Proteins Metabolism Aged Animals Host-pathogen Interactions Humans Immunity, Innate Lung Virology Respiratory Syncytial Virus Vaccines Chemistry Genetics Virus Replication Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Microbiology Applied Microbiology and Biotechnology |
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