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  1. Journal of Microbiology
  2. Year: 2017 Volume: 55
  3. Year: 2017 Volume: 55 Issue: 3
  4. Modulation of the host immune response by respiratory syncytial virus proteins.
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Year: 2017 Volume: 55
Year: 2017 Volume: 55 Issue: 3
Zika virus: An emerging flavivirus.
Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies.
The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic.
Modulation of the host immune response by respiratory syncytial virus proteins.
Exploiting virus-like particles as innovative vaccines against emerging viral infections.
H5 influenza, a global update
Year: 2017 Volume: 55 Issue: 2
Year: 2017 Volume: 55 Issue: 1
Year: 2016 Volume: 54
Year: 2015 Volume: 53
Year: 2014 Volume: 52
Year: 2013 Volume: 51
Year: 2012 Volume: 50
Year: 2011 Volume: 49
Year: 2010 Volume: 48
Year: 2009 Volume: 47

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Modulation of the host immune response by respiratory syncytial virus proteins.

Content Provider World Health Organization (WHO)-Global Index Medicus
Author Schmidt, Megan E. Varga, Steven M.
Description Country affiliation: United States Author Affiliation: Schmidt ME ( Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA.); Varga SM ( Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA. steven-varga@uiowa.edu.)
Abstract Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection.
File Format HTM / HTML
ISSN 12258873
Issue Number 3
Volume Number 55
e-ISSN 19763794
Journal Journal of Microbiology
Language English
Publisher Springer
Publisher Date 2017-03-01
Publisher Place Korea (South)
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Discipline Microbiology Immunomodulation Respiratory Syncytial Virus Infections Immunology Respiratory Syncytial Virus, Human Pathogenicity Viral Proteins Metabolism Aged Animals Host-pathogen Interactions Humans Immunity, Innate Lung Virology Respiratory Syncytial Virus Vaccines Chemistry Genetics Virus Replication Journal Article Review
Content Type Text
Resource Type Article
Subject Medicine Microbiology Applied Microbiology and Biotechnology
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