NDLI: The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients.

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The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Lianxi Yu, Haoyong Zhu, Jiaan Wu, Xing Liu, Fang Zhang, Feng Li, Qing Wu, Songhua Bao, Yuqian Jia, Weiping
Description	Country affiliation: China Author Affiliation: Li L ( Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai key Laboratory of Diabetes Mellitus, Shanghai, China.)
Abstract	OBJECTIVE: To evaluate the prevalence of atherosclerosis detected by both carotid and lower extremity ultrasonography in hospitalized Chinese type 2 diabetic patients and to examine whether plaque formation in the carotid arteries could be an indicator of generalized atherosclerosis in type 2 diabetes mellitus. METHODS: Totally, 709 hospitalized Chinese type 2 diabetic patients (men 357, women 352) aged from 18 to 88 years were included. Both carotid and lower extremity atherosclerosis were assessed by Doppler ultrasound. Atherosclerosis was defined as the presence of either the carotid or lower extremity plaque in any of the above-mentioned arteries segments. The prevalence of atherosclerosis was calculated, and the risk factors associated with atherosclerosis were evaluated using binary logistic regression. RESULTS: The prevalence of atherosclerosis was 81.23% in male and 77.56% in female type 2 diabetic patients, respectively. There was no significant difference in the prevalence of atherosclerosis in patients between the sexes. The prevalence of atherosclerosis was significantly higher in the lower extremity arteries than in the carotid arteries (73.91% and 44.43%, respectively, P<.001). Atherosclerosis was significantly associated with smoking, age, duration of diabetes, systolic blood pressure, total number of white blood cells, and mean carotid and femoral intima-media thickness (IMT). CONCLUSIONS: The prevalence of atherosclerosis was very high in Chinese inpatients with type 2 diabetes. Carotid atherosclerosis could not be an indicator of generalized atherosclerosis in type 2 diabetes. The combination of carotid and lower extremity ultrasound examination can significantly improve the detection of atherosclerosis in type 2 diabetes.
File Format	HTM / HTML
ISSN	10568727
Issue Number	1
Volume Number	26
e-ISSN	1873460X
Journal	Journal of Diabetes and its Complications
Language	English
Publisher	Elsevier
Publisher Date	2012-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Atherosclerosis Carotid Artery Diseases Diabetes Mellitus, Type 2 Diabetic Angiopathies Lower Extremity Adult Aged Asian Continental Ancestry Group Statistics & Numerical Data Diagnosis Epidemiology Carotid Intima-media Thickness Complications Female Hemoglobin A, Glycosylated Analysis Humans Leukocyte Count Male Middle Aged Prevalence Risk Factors Smoking Ultrasonography, Doppler Methods Journal Article
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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