NDLI: Serum albumin-adjusted glycated albumin is a better predictor of mortality in diabetic patients with end-stage renal disease on hemodialysis.

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Serum albumin-adjusted glycated albumin is a better predictor of mortality in diabetic patients with end-stage renal disease on hemodialysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yajima, Takahiro Yajima, Kumiko Hayashi, Makoto Yasuda, Keigo Takahashi, Hiroshi Yamakita, Noriyoshi
Description	Author Affiliation: Yajima T ( Department of Nephrology, Matsunami General Hospital, Gifu 501-6062, Japan. Electronic address: yajima5639@gmail.com.); Yajima K ( Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan.); Hayashi M ( Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan.); Yasuda K ( Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan.); Takahashi H ( Division of Medical Statistics, Fujita Health University School of Medicine, Aichi 470-1192, Japan.); Yamakita N ( Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan.)
Abstract	AIMS: Glycated albumin (GA) is a marker for monitoring glycemic control in diabetic patients with end-stage renal disease (ESRD). We evaluated whether serum albumin-adjusted GA (adjusted GA) could predict mortality in diabetic patients with ESRD on hemodialysis. METHODS: Seventy-eight patients with type 2 diabetes treated with regular hemodialysis were enrolled and followed up for 5-years. The adjusted GA was calculated from the regression formula and mean GA. The cut-off values for GA and adjusted GA that predicted mortality risk were determined using receiver operating characteristic curve analysis. RESULTS: During the follow-up period (median: 36months), 15 patients died. In the Kaplan-Meier analysis, there were no significant differences in the 5-year cumulative survival rate (58.3% [GA ≥19.8%] vs. 88.6% [GA <19.8%], P=0.075). Conversely, this rate was significantly higher in patients with adjusted GA <21.2% than adjusted GA ≥21.2% (86.4 vs. 49.5%, P=0.0068). After adjustment for other confounders, adjusted GA ≥21.2% was an independent predictor for mortality (hazard ratio 3.76, 95% confidence interval 1.12-17.44, P=0.031), but GA ≥19.8% was not (hazard ratio 2.63, 95% confidence interval 0.65-17.69, P=0.19). CONCLUSIONS: Adjusted GA is a better predictor of mortality than GA in diabetic patients with ESRD on hemodialysis.
File Format	HTM / HTML
ISSN	10568727
Issue Number	5
Journal	Journal of Diabetes and its Complications
Volume Number	30
e-ISSN	1873460X
Language	English
Publisher	Elsevier
Publisher Date	2016-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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