NDLI: Islet cell-associated autoantibodies in Ethiopians with diabetes mellitus.

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Islet cell-associated autoantibodies in Ethiopians with diabetes mellitus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siraj, Elias S. Gupta, Manjula K. Yifter, Helen Ahmed, Abdurezak Kebede, Tedla Reja, Ahmed Abdulkadir, Jemal
Description	Author Affiliation: Siraj ES ( Lewis Katz School of Medicine at Temple University, Section of Endocrinology, 3322North Broad St., Philadelphia, PA 19140, USA. Electronic address: elias.siraj@tuhs.temple.edu.); Gupta MK ( Cleveland Clinic, Department of Endocrinology, Diabetes & Metabolism, 9500 Euclid Avenue, Cleveland, OH 44195, USA.); Yifter H ( Addis Ababa University, Endocrine Unit, PO Box 9086, Addis Ababa, Ethiopia.); Ahmed A ( Addis Ababa University, Endocrine Unit, PO Box 9086, Addis Ababa, Ethiopia.); Kebede T ( Addis Ababa University, Endocrine Unit, PO Box 9086, Addis Ababa, Ethiopia.); Reja A ( Addis Ababa University, Endocrine Unit, PO Box 9086, Addis Ababa, Ethiopia.); Abdulkadir J ( Addis Ababa University, Endocrine Unit, PO Box 9086, Addis Ababa, Ethiopia.)
Abstract	BACKGROUND & AIMS: Our understanding of the role of autoimmunity in the pathogenesis of diabetes in African populations is limited. This study aims to evaluate the prevalence of 4 different islet cell-associated antibodies in Ethiopian patients with diabetes and non-diabetic controls. METHODS: A total of 187 subjects from a diabetic clinic at an Ethiopian hospital were evaluated in a cross-sectional study. Fifty-five patients had type 1 diabetes mellitus (T1DM), 86 had type 2 diabetes mellitus (T2DM) and 46 were non-diabetic controls. Islet cell-associated antibodies were measured using 4 different assays for antibodies against islet cells (ICA), glutamic acid decarboxylase (GADA), insulin (IAA) and the protein tyrosine phosphatase-like IA-2 (IA-2A). RESULTS: Comparing the antibody positivity in subjects with T1DM versus T2DM, the results were as follows: 29% versus 3.5% for GADA; 21% versus 2.7% for ICA; 27% versus 16% for IAA. In the control group, the only positive result was for IAA at 2%. IA-2A was absent in all groups. The combi-assay for GADA and IA-2A detected all GADA-positive subjects. T2DM patients who were GADA positive had lower BMI, lower C-peptide levels and all of them were on insulin therapy. CONCLUSIONS: Compared to Caucasians, Ethiopians with T1DM have less prevalence of islet cell-associated antibodies, but the rates are higher than in T2DM. GADA is present in Ethiopians, whereas IA-2A seems to be absent. GADA positivity in T2DM correlates with clinical features of T1DM, indicating the existence in Ethiopia of the subgroup, latent autoimmune diabetes in adults.
File Format	HTM / HTML
ISSN	10568727
Issue Number	6
Journal	Journal of Diabetes and its Complications
Volume Number	30
e-ISSN	1873460X
Language	English
Publisher	Elsevier
Publisher Date	2016-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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