NDLI: The pharmacokinetics of fluconazole in healthy Chinese adult volunteers: influence of ethnicity and gender.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guo, T. Sun, W-J Xia, D-Y Zhao, L-S
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Guo T ( Department of Pharmacy, Shenyang Northern Hospital, Shenyang, China. sy_guotao@263.net)
Abstract	OBJECTIVE: The purpose of the present study was to investigate and compare the influence of ethnicity (including Han, Mongolian, Korean, Hui and Uygur) and gender on the pharmacokinetics of fluconazole in healthy adult volunteers after administration of 200-mg fluconazole tablet. METHODS: Ten healthy subjects (five males and five females) of each ethnicity were recruited and given a single 200-mg dose of fluconazole in tablet form. Blood samples were obtained before dosing and at various predetermined time points after administration up to 96 h. Drug levels were measured by high-performance liquid chromatography. The blood concentration-time profiles were analyzed using a non-compartmental approach to estimate the absorption parameters (AUC((0-96)), C(max) and t(max)), the distribution parameter (V(d)) and the disposition parameters (t(1/2) and CL). RESULTS: Ethnicity did not affect the parameter estimates, but gender did. However, the gender differences in pharmacokinetic parameter could be accounted for by differences in weight. There was a high linear correlation between weight and ln C(max), ln AUC (ln means natural logarithmic transformation), V(d) and CL. CONCLUSIONS: Ethnicity (Chinese Han, Mongolian, Korean, Hui and Uygur) influences the pharmacokinetics of fluconazole tablet. However, there were statistically significant gender differences in AUC, C(max), V(d) and CL. But these could be accounted for by weight differences. If fluconazole dose-adjustment is deemed necessary, this can be done on a weight basis rather than gender basis.
File Format	HTM / HTML
ISSN	02694727
Issue Number	2
Volume Number	35
e-ISSN	13652710
Journal	Journal of Clinical Pharmacy and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology Antifungal Agents Pharmacokinetics Asian Continental Ancestry Group Ethnology Fluconazole Administration, Oral Area Under Curve China Female Humans Male Sex Factors Tablets Tissue Distribution Young Adult Clinical Trial Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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