NDLI: Influence of the number of daily pills and doses on adherence to antiretroviral treatment: a 7-year study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hernández Arroyo, M. J. Cabrera Figueroa, S. E. Sepúlveda Correa, R. Valverde Merino, M. P. Luna Rodrigo, G. Domínguez-Gil Hurlé, A.
Description	Country affiliation: Spain Author Affiliation: Hernández Arroyo MJ ( Pharmacy Service, University Hospital of Salamanca, Salamanca, Spain.); Cabrera Figueroa SE ( Pharmacy Institute, University Austral of Chile, Valdivia, Chile.); Sepúlveda Correa R ( Department of Statistics, University of Salamanca, Salamanca, Spain.); Valverde Merino MP ( Pharmacy Service, University Hospital of Salamanca, Salamanca, Spain.); Luna Rodrigo G ( Infectious Disease Service, University Hospital of Salamanca, Salamanca, Spain.); Domínguez-Gil Hurlé A ( Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Salamanca, Spain.)
Abstract	WHAT IS KNOWN AND OBJECTIVE: Antiretroviral treatment (ART) is hampered by complicated regimens, high pill burden, drug-drug interactions, and frequent short- and long-term adverse effects, leading to decreased adherence. Over recent years, considerable effort has been directed at developing regimens that are less burdening. We undertook a 7-year retrospective study of the records of 264 HIV-infected subjects enrolled in a pharmaceutical care programme to document the progress made and to study the influence of the number of ART pills and doses on the level of treatment adherence. METHODS: Antiretroviral dispensing records were analysed for the number of pills and doses administered and the ART adherence rate estimated. RESULTS AND DISCUSSION: In 2005, the patients took a mean of 6·2 pills daily (CI 95%: 5·9-6·6), and 92·9% of them were on a twice-a-day (BID) dosage regimen. By 2012, the mean number of pills was reduced to 4·1 (CI 95%: 3·8-4·4), and only 50·9% were on a BID regimen. No statistically significant relation was observed between number of daily pills and doses and ART adherence reached by the patients in any of the analyses performed. WHAT IS NEW AND CONCLUSIONS: There has been a continuous reduction in the number of pills and doses of antiretrovirals taken by individual patients over the last 7 years due largely to the introduction of improved treatments and regimens. More daily pills or doses was not associated with worse ART adherence in our pharmaceutical care programme.
File Format	HTM / HTML
ISSN	02694727
Issue Number	1
Volume Number	41
e-ISSN	13652710
Journal	Journal of Clinical Pharmacy and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology Anti-hiv Agents Administration & Dosage Hiv Infections Drug Therapy Medication Adherence Pharmaceutical Services Organization & Administration Adult Therapeutic Use Drug Administration Schedule Female Humans Male Middle Aged Retrospective Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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