NDLI: Factors associated with atomoxetine efficacy for treatment of attention-deficit/hyperactivity disorder in children and adolescents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Scott, Nakia Gray Ripperger-Suhler, Jane Rajab, M. Hasan Kjar, Dean
Description	Country affiliation: United States Author Affiliation: Scott NG ( Texas A&M University System Health Science Center/Scott and White Memorial Hospital, Child and Adolescent Mental Health Clinic, Temple, Texas, USA.)
Abstract	OBJECTIVES: The aims of this study were to determine if relationships exist between the efficacy of atomoxetine for treatment of attention-deficit/hyperactivity disorder (ADHD) and demographic characteristics, specific co-morbid diagnoses, subtype of ADHD, and/or additional use of a stimulant medication. METHOD: A retrospective chart review was performed using data from an institutional electronic medical record system. Children aged 5-17 years who were diagnosed with ADHD and prescribed atomoxetine were included; 432 study subjects were categorized as treatment success (TS), treatment failure (TF), or undetermined. Co-morbid diagnoses, demographic factors, subtype of ADHD, and additional use of stimulant medications were examined for association with TS. RESULTS: A total of 88 children were categorized as TS, 197 as TF, and 147 as undetermined. More subjects in the TS group were receiving stimulant medication in addition to the atomoxetine than in the TF group (p = 0.0319; 95% Wald confidence interval [CI], 1.064-3.972). There was no significant difference between groups for any demographic characteristic, the presence of any co-morbid diagnosis, or type of ADHD. In particular, the presence of anxiety or depression was not associated with a response to atomoxetine. CONCLUSION: Children who were prescribed a stimulant medication in addition to atomoxetine had better outcomes in treating ADHD than those receiving only atomoxetine.
File Format	HTM / HTML
ISSN	10445463
Issue Number	3
Volume Number	20
e-ISSN	15578992
Journal	Journal of Child and Adolescent Psychopharmacology
Language	English
Publisher	Mary Ann Liebert
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Pediatrics Adrenergic Uptake Inhibitors Therapeutic Use Attention Deficit Disorder With Hyperactivity Drug Therapy Propylamines Adolescent Anxiety Complications Atomoxetine Hydrochloride Physiopathology Central Nervous System Stimulants Child Child, Preschool Depression Drug Therapy, Combination Electronic Health Records Female Humans Male Retrospective Studies Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Pediatrics, Perinatology and Child Health Psychiatry and Mental Health

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