NDLI: New cationic biodegradable poly(urethane-co-ester): synthesis, structural characterization, modification and gene delivery.

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New cationic biodegradable poly(urethane-co-ester): synthesis, structural characterization, modification and gene delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chang, Wei-Yang Hsiao, Yu-Che Shau, Min-Da
Description	Author Affiliation: Chang WY ( Department of Biotechnology, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Road, Sec 1, Jen-Te, Taiwan, ROC.)
Abstract	To improve the transfection efficiency of poly(urethane-co-ester) and the cytotoxicity of PEI25k with DNA, we synthesized a new poly(urethane-co-ester), PUE, bearing ester linkages and amino groups in the backbone and urethane linkages in the side-chain, and then prepared a binary mixture, PUE-PEI25k, using a physical blending method. The structure of PUE was confirmed by FT-IR and NMR spectra. Both poly(urethane-co-ester), PUE, and binary mixture PUE-PEI25k, readily self-assembled with plasmid DNA (pCMV-ßgal) in a HEPES buffer, were characterized by dynamic light scattering. The results revealed that PUE and PUE-PEI25k were able to self-assemble plasmid DNA into PUE/DNA and PUE-PEI25k/DNA nano-complexes small enough to enter a cell through endocytosis. Titration studies were performed to determine the buffering capacities of PUE and PUE-PEI25k. The COS-7 cell viability in the presence of PEI25k, PUE and PUE-PEI25k was studied. At low mass ratio of PUE/PEI25k (150:1), it was found that the PUE-PEI25k/DNA complexes were able to transfect COS-7 cells in vitro with a high efficiency comparable to a well-known gene carrier, PEI25k/DNA. The results indicate that the binary mixture PUE-PEI25k is an attractive cationic carrier for gene delivery and an interesting candidate for further study.
File Format	HTM / HTML
ISSN	09205063
Issue Number	1-4
Volume Number	23
e-ISSN	15685624
Journal	Journal of Biomaterials Science, Polymer Edition
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering Drug Carriers Chemistry Chemical Synthesis Polyesters Polyurethanes Transfection Methods Animals Cos Cells Cercopithecus Aethiops Dna Genetics Metabolism Toxicity Hydrolysis Particle Size Plasmids Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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New cationic biodegradable poly(urethane-co-ester): synthesis, structural characterization, modification and gene delivery.

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New cationic biodegradable poly(urethane-co-ester): synthesis, structural characterization, modification and gene delivery.