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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hegedüs, Nikoletta Sigl, Claudia Zadra, Ivo Pócsi, Istvan Marx, Florentine |
| Description | Country affiliation: Austria Author Affiliation: Hegedüs N ( Biocenter, Division of Molecular Biology, Innsbruck Medical University, Innsbruck, Austria.) |
| Abstract | Penicillium chrysogenum secretes a low molecular weight, cationic and cysteine-rich protein (PAF). It has growth inhibitory activity against the model organism Aspergillus nidulans and numerous zoo- and phytopathogenic fungi but shows only minimal conditional antifungal activity against the producing organism itself. In this study we provide evidence for an additional function of PAF which is distinct from the antifungal activity against putative ecologically concurrent microorganisms. Our data indicate that PAF enhances conidiation in P. chrysogenum by modulating the expression of brlA, the central regulatory gene for mitospore development. A paf deletion strain showed a significant impairment of mitospore formation which sustains our hypothesis that PAF plays an important role in balancing asexual differentiation in P. chrysogenum. |
| File Format | HTM / HTML |
| ISSN | 0233111X |
| e-ISSN | 15214028 |
| DOI | 10.1002/jobm.201000321 |
| Journal | Journal of Basic Microbiology |
| Issue Number | 3 |
| Volume Number | 51 |
| Language | English |
| Publisher | Wiley-VCH Verlag |
| Publisher Date | 2011-06-01 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Discipline Microbiology Fungal Proteins Metabolism Penicillium Chrysogenum Growth & Development Recombination, Genetic Spores, Fungal Gene Expression Regulation, Fungal Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Applied Microbiology and Biotechnology |
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