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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hou, Xiang-Hua Zhang, Jia-Qin Song, Xiu-Yu Ma, Xiao-Bo Zhang, Shi-Yang |
| Description | Country affiliation: China Author Affiliation: Hou XH ( Department of Clinical Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen, China.) |
| Abstract | Abilities to tolerate environmental stresses and to form biofilms on teeth surface are key virulence attributes of Streptococcus mutans, the primary causative agent of human dental caries. ClpP, the chief intracellular protease of S. mutans, along with ATPases degrades altered proteins that might be toxic for bacteria, and thus plays important roles in stress response. To further understand the roles of ClpP in stress response of S. mutans, a ClpP deficient strain was constructed and used for general stress tolerance, autolysis, mutacins production, and virulence assays. Here, we demonstrated that inactivation of ClpP in S. mutans resulted in a sensitive phenotype to several environmental stresses, including acid, cold, thermal, and oxidative stresses. The ClpP deficient strain displayed slow growth rates, poor growth yields, formation of long chains, increased clumping in broth, and reduced capacity to form biofilms in presence of glucose. Mutacins production and autolysis of S. mutans were also impaired by mutation of clpP. Animals study showed that clpP mutation increased virulence of S. mutans but not significant. However, enhanced abilities to survive lethal acid and to form biofilm in sucrose were observed in ClpP deficient strain. Our findings revealed a broad impact of ClpP on several virulence properties of S. mutans and highlighted the relevance of ClpP proteolysis with progression of diseases caused by S. mutans. |
| File Format | HTM / HTML |
| ISSN | 0233111X |
| Issue Number | 11 |
| Volume Number | 54 |
| e-ISSN | 15214028 |
| Journal | Journal of Basic Microbiology |
| Language | English |
| Publisher | Wiley-VCH Verlag |
| Publisher Date | 2014-11-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Endopeptidase Clp Metabolism Streptococcus Mutans Enzymology Physiology Stress, Physiological Animals Bacteriocins Bacteriolysis Biofilms Growth & Development Disease Models, Animal Genetics Gene Deletion Streptococcal Infections Microbiology Pathology Virulence Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Applied Microbiology and Biotechnology |
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