NDLI: Environmental epigenetics: from novelty to scientific discipline.

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Environmental epigenetics: from novelty to scientific discipline.

Year: 2014 Volume: 34 Issue: 1

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Environmental epigenetics: from novelty to scientific discipline.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Burris, Heather H. Baccarelli, Andrea A.
Description	Country affiliation: United States Author Affiliation: Burris HH ( Department of Neonatology, Beth Israel Deaconess Medical Center & Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.)
Abstract	Epigenetic phenomena have sparked much interest resulting in an exponential increase in scientific investigation in the last two decades. While growing, the field of environmental epigenetics remains small when compared to other areas of epigenetic inquiry such as cancer research. In this paper, our objective is to describe the status of the field of environmental epigenetics and lay out our vision for its future. While environmental epigenetic studies represent fewer than 5% of all epigenetic publications, the National Institute of Environmental Health Sciences ranks second in proportion of dollars spent on epigenetics of all NIH Institutes. Such investment highlights the hypothesis that epigenetic marks are modified by environmental exposures and the hope that interventions targeted at epigenetic mechanisms may ultimately lead to improved health outcomes. The road to achieve this vision will require: (1) attention to tissue specificity; (2) focused interventional studies; (3) collaboration among cohorts; (4) inclusion of environmental exposures in new large-scale epigenomic studies; and (5) understanding of multiple mechanisms beyond DNA methylation and histone modifications. The investment in environmental epigenetic inquiry will lead to great rewards if we can understand the biology of how phenotype results from environmental stimuli and genetic code. Understanding the epigenetic implications of our actions and exposures may benefit generations to come.
File Format	HTM / HTML
ISSN	0260437X
e-ISSN	10991263
DOI	10.1002/jat.2904
Journal	Journal of Applied Toxicology
Issue Number	2
Volume Number	34
Language	English
Publisher	Wiley
Publisher Date	2014-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Toxicology Environmental Exposure Environmental Pollutants Toxicity Epigenesis, Genetic Gene-environment Interaction Dna Methylation Genome, Human Histones Genetics Metabolism Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Toxicology

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