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Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flores-Montoya, Mayra Gisel Sobin, Christina
Description	Country affiliation: United States Author Affiliation: Flores-Montoya MG ( Border Biomedical Research Center, Toxicology Core, University of Texas, El Paso, TX, USA.); Sobin C ( Department of Psychology, University of Texas, El Paso, TX, USA.)
Abstract	Research has suggested that chronic low-level lead exposure diminishes neurocognitive function in children. Tests that are sensitive to behavioral effects at lowest levels of lead exposure are needed for the development of animal models. In this study we investigated the effects of chronic low-level lead exposure on exploratory activity (unbaited nose poke task), exploratory ambulation (open field task) and motor coordination (Rotarod task) in pre-adolescent mice. C57BL/6J pups were exposed to 0 ppm (controls), 30 ppm (low-dose) or 230 ppm (high-dose) lead acetate via dams' drinking water administered from birth to postnatal day 28, to achieve a range of blood lead levels (BLLs) from not detectable to 14.84 µg dl(-1) ). At postnatal day 28, mice completed behavioral testing and were killed (n = 61). BLLs were determined by inductively coupled plasma mass spectrometry. The effects of lead exposure on behavior were tested using generalized linear mixed model analyses with BLL, sex and the interaction as fixed effects, and litter as the random effect. BLL predicted decreased exploratory activity and no threshold of effect was apparent. As BLL increased, nose pokes decreased. The C57BL/6J mouse is a useful model for examining effects of early chronic low-level lead exposure on behavior. In the C57BL/6J mouse, the unbaited nose poke task is sensitive to the effects of early chronic low-level lead exposure. This is the first animal study to show behavioral effects in pre-adolescent lead-exposed mice with BLL below 5 µg dl(-1).
File Format	HTM / HTML
ISSN	0260437X
e-ISSN	10991263
DOI	10.1002/jat.3064
Journal	Journal of Applied Toxicology
Issue Number	7
Volume Number	35
Language	English
Publisher	Wiley
Publisher Date	2015-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Toxicology Exploratory Behavior Drug Effects Lead Poisoning, Nervous System, Childhood Psychology Animals Behavior, Animal Dose-response Relationship, Drug Blood Mice Mice, Inbred C57bl Rotarod Performance Test Spectrophotometry, Atomic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Toxicology

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