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Neuropsychological function in patients with anorexia nervosa or bulimia nervosa.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weider, Siri Indredavik, Marit Saebø Lydersen, Stian Hestad, Knut
Description	Country affiliation: Norway Author Affiliation: Weider S ( Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway)
Abstract	OBJECTIVE: This study explored the neuropsychological performance of patients diagnosed with anorexia nervosa (AN) or bulimia nervosa (BN) compared with healthy controls (HCs). An additional aim was to investigate the effect of several possible mediators on the association between eating disorders (EDs) and cognitive function. METHOD: Forty patients with AN, 39 patients with BN, and 40 HCs who were comparable in age and education were consecutively recruited to complete a standardized neuropsychological test battery covering the following cognitive domains: verbal learning and memory, visual learning and memory, speed of information processing, visuospatial ability, working memory, executive function, verbal fluency, attention/vigilance, and motor function. RESULTS: The AN group scored significantly below the HCs on eight of the nine measured cognitive domains. The BN group also showed inferior performance on six cognitive domains. After adjusting for possible mediators, the nadir body mass index (lowest lifetime BMI) and depressive symptoms explained all findings in the BN group. Although this adjustment reduced the difference between the AN and HC groups, the AN group still performed worse than the HCs regarding verbal learning and memory, visual learning and memory, visuospatial ability, working memory, and executive functioning. DISCUSSION: Patients with EDs scored below the HCs on several cognitive function measures, this difference being most pronounced for the AN group. The nadir BMI and depressive symptoms had strong mediating effects. Longitudinal studies are needed to identify the importance of weight restoration and treatment of depressive symptoms in the prevention of a possible cognitive decline.
File Format	HTM / HTML
ISSN	02763478
Issue Number	4
Volume Number	48
e-ISSN	1098108X
Journal	International Journal of Eating Disorders
Language	English
Publisher	Wiley
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Behavioral Sciences Anorexia Nervosa Physiopathology Bulimia Nervosa Cognition Disorders Adolescent Adult Psychology Attention Physiology Body Weight Case-control Studies Cognition Depression Executive Function Female Humans Longitudinal Studies Male Middle Aged Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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