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Primary CNS lymphoma treated with radiotherapy in Japan: a survey of patients treated in 2005-2009 and a comparison with those treated in 1985-2004.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shibamoto, Yuta Sumi, Minako Onodera, Shunsuke Matsushita, Haruo Sugie, Chikao Tamaki, Yukihisa Onishi, Hiroshi Abe, Eisuke Koizumi, Masahiko Miyawaki, Daisuke Kubota, Seiji Ogo, Etsuyo Nomiya, Takuma Takemoto, Mitsuhiro Harada, Hideyuki Takahashi, Ippei Ohmori, Yoshio Ishibashi, Naoya Tokumaru, Sunao Suzuki, Kazunori
Spatial Coverage	Japan
Description	Author Affiliation: Shibamoto Y ( Department of Radiology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Nagoya, Aichi, 467-8601, Japan, yshiba@med.nagoya-cu.ac.jp.)
Abstract	BACKGROUND: The aim of our study was to analyze changes over time in the characteristics, treatment, and outcome of patients with primary central nervous system lymphoma (PCNSL). METHODS: Data on 315 patients with histologically proven PCNSL undergoing radiotherapy between 2005 and 2009 were collected from 20 Japanese institutions using a questionnaire. These data were then compared with data on 273 patients treated during the period 1995-2004 and those on 466 patients treated during the period 1985-1994. RESULTS: In terms of patient and tumor characteristics, we found a significant increase in mean patient age in the 2005-2009 period compared to the 1985-2004 period (63 vs. 58-59 years, respectively) and in the percentage of patients with better performance status (PS) during the 2005-2009 period compared with the 1995-2004 period (World Health Organization PS 0-2: 73 vs. 65 %, respectively). Regarding treatment, relative to the 1995-2004 period, significant changes in the 2005-2009 period were (1) decreased rate of attempting tumor resection (23 vs. 44 %); (2) increased use of chemotherapy (78 vs. 68 %), and (3) increased use of methotrexate (MTX)-containing regimens (84 vs. 53 %). The 5-year overall survival rates were 15.3, 30.1, and 36.5 % for patients seen during the 1985-1994, 1995-2004, and 2005-2009 periods, respectively, but relapse-free survival did not improve between the 1995-2004 and 2005-2009 periods (26.7 vs. 25.7 % at 5 years, respectively). Patients receiving MTX-containing chemotherapy had 5-year survival rates of 19, 50, and 44 % during these three periods, respectively. CONCLUSIONS: Although patient backgrounds differed among the study periods, recent trends were a high patient age, better PS, avoidance of extensive tumor resection, more frequent use of chemotherapy, and improved survival. The recent improvement in survival may be due to improvements in second-line treatment and supportive care.
File Format	HTM / HTML
ISSN	13419625
Issue Number	5
Volume Number	19
e-ISSN	14377772
Journal	International Journal of Clinical Oncology
Language	English
Publisher	Springer
Publisher Date	2014-10-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Central Nervous System Neoplasms Radiotherapy Central Nervous System Pathology Lymphoma Neoplasm Recurrence, Local Adult Aged Radiation Effects Drug Therapy Female Humans Japan Male Methotrexate Administration & Dosage Middle Aged Questionnaires Survival Rate Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hematology Surgery Oncology

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