NDLI: A meta analysis of cetuximab plus oxaliplatin based chemotherapy regimen for metastatic colorectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, Y. L. Lou, J. Guo, J. Y. Huang, Z. Lv, S. W.
Description	Author Affiliation: Lv SW ( Department of Clinical Pharmacy, The Central Hospital of Jinhua City, Jinhua Zhejiang Province 321000, China.)
Abstract	BACKGROUND: Oxaliplatin based chemotherapy regimen was one of the most used chemotherapy modality for metastatic colorectal cancer. The purpose of this meta-analysis was to assess the clinical activity and toxicities of cetuximab plus oxaliplatin-based chemotherapy regimen for metastatic colorectal Cancer. METHODS: We searched the clinical studies about the cetuximab plus oxaliplatin-based chemotherapy regimen versus oxaliplatin-based chemotherapy alone for metastatic colorectal cancer in the databases of PubMed, EMBASE, Cochran, and CNKI. The data of response and toxicities were extracted and pooled by random or fixed effects model. And publication bias was evaluated by begg's funnel plot and egger's regression test. RESULTS: Seven papers were included in this study. Adding cetuximab to oxaliplatin-based chemotherapy regime can significant increase response rate in K-RAS mutation metastatic colorectal patients (odds ratio [OR]: 1.45, 95% confidence interval [CI]: 1.17-1.80, Z = 3.38, P = 0.001) and metastatic colorectal patients without knowing the K-RAS status (OR: 1.36, 95% CI: 1.11-1.65, Z = 1.89, P = 0.003). But for patients with mutated K-RAS, the improvement for objective response rate was not statistical significant (OR: 0.70, 95% CI: 0.49-1.01, Z = 3.00, P = 0.058) when adding cetuximab to oxaliplatin-based chemotherapy regime. The pooled results indicating the rash and diarrhea risk was significantly increased in the combined treatment group (P < 0.05). The toxicity of peripheral neuritis was decreased by adding the cetuximab (P < 0.05). And other toxicities were not statistical different between the two groups (P > 0.05). Significant publication bias was found in toxicities evaluation. CONCLUSION: Cetuximab plus oxaliplatin-based chemotherapy regimen significant increase the response rate for metastatic colorectal cancer. But the some toxicities such rash and diarrhea risk was also increased.
File Format	HTM / HTML
ISSN	0019509X
Issue Number	Suppl 3
Volume Number	51
e-ISSN	19984774
Journal	Indian Journal of Cancer
Language	English
Publisher	Medknow Publications
Publisher Date	2014-03-01
Publisher Place	India
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Colorectal Neoplasms Drug Therapy Secondary Antibodies, Monoclonal, Humanized Administration & Dosage Cetuximab Humans Organoplatinum Compounds Prognosis Journal Article Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Oncology

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