NDLI: CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.

Please wait, while we are loading the content...

Mitochondrial COX2 G7598A mutation may have a modifying role in the phenotypic manifestation of aminoglycoside antibiotic-induced deafness associated with 12S rRNA A1555G mutation in a Han Chinese pedigree.

The LRRK2 gene is mutated in a Chinese autosomal-dominant Parkinson's disease family.

Perception, experience, and response to genetic discrimination in Huntington's disease: the Australian results of The International RESPOND-HD study.

Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.

BCR-ABL1 kinase domain mutation analysis in an Irish cohort of chronic myeloid leukemia patients.

The proto-oncogene KRAS and BRAF profiles and some clinical characteristics in colorectal cancer in the Turkish population.

CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.

The association between development and progression of multinodular goiter and thyroid-stimulating hormone receptor gene D727E and P52T polymorphisms.

Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.

Year: 2013 Volume: 17 Issue: 1

Year: 2012 Volume: 16

Year: 2011 Volume: 15

Year: 2010 Volume: 14

Year: 2009 Volume: 13

CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Xiujun Zuo, Jinliang Guo, Tao Yuan, Li
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Wu X ( Department of Pharmacy, Shenyang Northern Hospital, China.)
Abstract	PURPOSE: To determine the allele frequency of three codon-changing variants (CYP2C82, CYP2C83, and CYP2C84) in the Han, Uighur, Hui, and Mongolian Chinese populations, and compare genetic polymorphism differences between the Han and minority Chinese ethnicities. METHODS: Five hundred seventy four healthy unrelated volunteers from four major nationalities (Han: 136; Uighur: 153; Hui: 158; Mongolian: 127) in China were recruited. The study was approved by the local research ethics committee. DNA was extracted from peripheral leukocytes using a standard protocol. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was developed to detect three alleles of CYP2C8. PCR results were confirmed by subsequent direct DNA sequencing. RESULTS: The three minorities showed the CYP2C8 polymorphism with an allele frequency as follows: the allele frequencies of CYP2C82, CYP2C83, and CYP2C84 were 0.33%, 2.94%, and 2.29% in Uighur; 0.39%, 1.57%, and 1.18% in Mongolian, and 0%, 1.58%, and 0.63% in Hui, respectively. For Han, CYP2C82, CYP2C83, and CYP2C8*4 were absent. CONCLUSION: To the best of our knowledge, the current study described polymorphisms of CYP2C8 in Chinese minorities for the first time. The results showed that there were significant ethnic differences in the distribution of CYP2C8 in the Han and three minorities, that is, the Uighur, Hui, and Mongolian Chinese populations.
File Format	HTM / HTML
ISSN	19450265
Issue Number	2
Volume Number	17
e-ISSN	19450257
Journal	Genetic Testing and Molecular Biomarkers
Language	English
Publisher	Mary Ann Liebert
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Genetics Discipline Molecular Biology Aryl Hydrocarbon Hydroxylases Genetics Asian Continental Ancestry Group Ethnology Gene Frequency Polymorphism, Genetic Adult Alleles China Cytochrome P-450 Cyp2c8 Genotype Humans Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Sequence Analysis, Dna Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Allele and genotype frequencies of CYP3A4, CYP2C19, and CYP2D6 in Han, Uighur, Hui, and Mongolian Chinese populations.

Differences in genotype and allele frequency distributions of polymorphic drug metabolizing enzymes CYP2C19 and CYP2D6 in mainland Chinese Mongolian, Hui and Han populations.

Differences between Spaniards and Ecuadorians in CYP2A6 allele frequencies: comparison with other populations.

Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations.

Allele and genotype frequencies of CYP2C9 within an Iranian population (Mazandaran).

Genetic polymorphisms of CYP2C8 in the Czech Republic.

Prevalence of CYP2C8 polymorphisms in a North Indian population.

Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China.

Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.

CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.

Similar Documents

Allele and genotype frequencies of CYP3A4, CYP2C19, and CYP2D6 in Han, Uighur, Hui, and Mongolian Chinese populations.

Differences in genotype and allele frequency distributions of polymorphic drug metabolizing enzymes CYP2C19 and CYP2D6 in mainland Chinese Mongolian, Hui and Han populations.

Differences between Spaniards and Ecuadorians in CYP2A6 allele frequencies: comparison with other populations.

Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations.

Allele and genotype frequencies of CYP2C9 within an Iranian population (Mazandaran).

Genetic polymorphisms of CYP2C8 in the Czech Republic.

Prevalence of CYP2C8 polymorphisms in a North Indian population.

Association of a CYP4A11 polymorphism and hypertension in the Mongolian and Han populations of China.

Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population.

CYP2C8 polymorphism frequencies among Han, Uighur, Hui, and Mongolian Chinese populations.