NDLI: Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.

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Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.

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Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Belinsky, Martin G. Rink, Lori Flieder, Douglas B. Jahromi, Mona S. Schiffman, Joshua D. Godwin, Andrew K. Mehren, Margaret von
Description	Country affiliation: United States Author Affiliation: Belinsky MG ( Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA. Martin.Belinsky@fccc.edu)
Abstract	Approximately 15% of gastrointestinal stromal tumors (GISTs) in adults and 85% in children lack mutations in KIT and PDGFRA and are known as wild-type GISTs. Wild-type GISTs from adults and children express high levels of insulin-like growth factor 1 receptor (IGF1R) and exhibit stable genomes compared to mutant GISTs. Pediatric wild-type GISTs, GISTs from the multitumor Carney-Stratakis syndrome, and the Carney triad share other clinicopathological properties (e.g., early-onset, multifocal GISTs with epitheliod cell morphology), suggesting a common etiology. Carney-Stratakis is an inherited association of GIST and paragangliomas caused by germline mutations in succinate dehydrogenase (SDH) genes. The connection between defective cellular respiration and GIST pathology has been strengthened by the utilization of SDHB immunohistochemistry to identify SDH deficiency in pediatric GISTs, syndromic GISTs, and some adult wild-type GISTs. SDHB and IGF1R expression was examined in 12 wild-type and 12 mutant GIST cases. Wild-type GISTs were screened for coding-region alterations in SDH genes and for chromosomal aberrations using genome-wide single-nucleotide polymorphism and MIP arrays. SDHB-deficiency, identified in 11/12 wild-type GIST cases, was tightly associated with overexpression of IGF1R protein and transcript. Biallelic inactivation of the SDHA gene was a surprisingly frequent event, identified in 5 of 11 SDHB-negative cases, generally due to germline point mutations accompanied by somatic SDHA allelic losses. As a novel finding, inactivation of the SDHC gene from a combination of a heterozygous coding-region mutation and hypermethylation of the wild-type allele was found in one SDHB-negative case.
File Format	HTM / HTML
ISSN	10452257
e-ISSN	10982264
DOI	10.1002/gcc.22023
Journal	Genes, Chromosomes and Cancer
Issue Number	2
Volume Number	52
Language	English
Publisher	Wiley-Liss
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology Discipline Oncology Electron Transport Complex Ii Genetics Gastrointestinal Neoplasms Gastrointestinal Stromal Tumors Mutation Receptor, Igf Type 1 Succinate Dehydrogenase Adolescent Dna Mutational Analysis Metabolism Gene Expression Regulation, Neoplastic Immunohistochemistry Molecular Sequence Data Proto-oncogene Proteins B-raf Proto-oncogene Proteins C-kit Receptor, Platelet-derived Growth Factor Alpha Reverse Transcriptase Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research

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