NDLI: Antifungal activity of extracts and isolated compounds from Buchenavia tomentosa on Candida albicans and non-albicans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Teodoro, Guilherme R. Brighenti, Fernanda L. Delbem, Alberto C. Botazzo Delbem, Ádina Cléia B. Khouri, Sonia Gontijo, Aline Vidal L. Pascoal, Aislan Crf Salvador, Marcos J. Koga-Ito, Cristiane Y.
Description	Country affiliation: Brazil Author Affiliation: Teodoro GR ( Oral Biopathology Graduate Program, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.); Brighenti FL ( Department of Orthodontics & Pediatric Dentistry, Araraquara Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.); Delbem AC ( Department of Pediatric Dentistry, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.); Delbem ÁC ( Department of Pediatric Dentistry, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.); Khouri S ( Faculdade de Ciências da Saúde, Universidade do Vale do Paraíba (UNIVAP), São José dos Campos, São Paulo, Brazil.); Gontijo AV ( Department of Environmental Engineering, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.); Pascoal AC ( Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.); Salvador MJ ( Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.); Koga-Ito CY ( Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.)
Abstract	AIM: This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species. MATERIALS & METHODS: The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated. RESULTS: Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata. CONCLUSION: Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata.
File Format	HTM / HTML
ISSN	17460913
Issue Number	6
Volume Number	10
e-ISSN	17460921
Journal	Future Microbiology
Language	English
Publisher	Future Medicine
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Microbiology Antifungal Agents Pharmacology Candida Drug Effects Combretaceae Chemistry Plant Extracts 3t3 Cells Animals Isolation & Purification Toxicity Cell Survival Fibroblasts Mice Mice, Inbred Balb C Microbial Sensitivity Tests Spectrum Analysis Journal Article
Content Type	Text
Resource Type	Article
Subject	Microbiology Microbiology (medical)

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