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Spatially resolved two-photon irradiation of an intracellular singlet oxygen photosensitizer: correlating cell response to the site of localized irradiation.

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Spatially resolved two-photon irradiation of an intracellular singlet oxygen photosensitizer: correlating cell response to the site of localized irradiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gollmer, A. Besostri, F. Breitenbach, T. Ogilby, P. R.
Description	Country affiliation: Denmark Author Affiliation: Gollmer A ( Department of Chemistry, Center for Oxygen Microscopy and Imaging, Aarhus University, Aarhus, Denmark.)
Abstract	The response of HeLa cells to subcellular spatially localized two-photon irradiation of a singlet oxygen photosensitizer (protoporphyrin IX, PpIX) using a focused laser was assessed. Upon irradiation under these conditions, a localized population of PpIX excited states can be produced with meaningful intracellular spatial resolution; the dimensions of the domain where the incident light flux is high enough for PpIX two-photon absorption are defined by the microscope optics and by the diffraction of light (spot diameter at beam waist of Ë 0.5-1.0 µm). In turn, the dimensions of the intracellular domain containing cytotoxic PpIX-sensitized singlet oxygen will likewise be confined. Most importantly, cell response (e.g., morphological signs of cell death) correlates with the light dose delivered and the intracellular domain irradiated. Thus, controlling light delivery can complement other techniques used to impart intracellular spatial localization in mechanistic studies of photoinitiated reactive oxygen species. Such controlled light delivery is also expected to be a particularly useful tool to study the so-called bystander effect in which a selectively-perturbed cell can influence a neighboring cell through intercellular signaling mechanisms.
File Format	HTM / HTML
ISSN	10715762
Issue Number	9
Volume Number	47
e-ISSN	10292470
Journal	Free Radical Research
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Photons Photosensitizing Agents Metabolism Protoporphyrins Singlet Oxygen Apoptosis Radiation Effects Bystander Effect Hela Cells Humans Lasers Light Signal Transduction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry

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