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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Closa, Daniel |
| Description | Country affiliation: Spain Author Affiliation: Closa D ( Department of Experimental Pathology, IIBB-CSIC-IDIBAPS, CIBEREHD , Barcelona , Spain.) |
| Abstract | There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is also involved in the progression of the disease from a local damage to a systemic organ failure. However, therapeutic use of antioxidants failed to clearly show a clinical benefit in different trials. Therefore, although antioxidants alone seem to be not enough for the treatment of severe acute pancreatitis, future combined therapeutic strategies should include antioxidants in its composition. |
| File Format | HTM / HTML |
| ISSN | 10715762 |
| Issue Number | 11 |
| Volume Number | 47 |
| e-ISSN | 10292470 |
| Journal | Free Radical Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Free Radicals Metabolism Pancreatitis Acute Disease Animals Humans Lipid Peroxidation Oxidative Stress Physiology Drug Therapy Pancreatitis, Acute Necrotizing Reactive Oxygen Species Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry |
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