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Imaging mitochondrial reactive oxygen species with fluorescent probes: current applications and challenges.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, X. Gao, F.
Description	Author Affiliation: Zhang X ( Department of Aerospace Medicine, Fourth Military Medical University , Xi'an , P. R. China.)
Abstract	Mitochondrial reactive oxygen species (ROS) is a key element in the regulation of several physiological functions and in the development or progression of multiple pathological events. A key task in the study of mitochondrial ROS is to establish reliable methods for measuring the ROS level in mitochondria with high selectivity, sensitivity, and spatiotemporal resolution. Over the last decade, imaging tools with fluorescent indicators from either small-molecule dyes or genetically encoded probes that can be targeted to mitochondria have been developed, which provide a powerful method to visualize and even quantify mitochondrial ROS level not only in live cells, but also in live animals. These innovative tools that have bestowed exciting new insights in mitochondrial ROS biology have been further promoted with the invention of new techniques in indicator design and fluorescent detection. However, these probes present some limitations in terms of specificity, sensitivity, and kinetics; failure to recognize these limitations often results in inappropriate interpretations of data. This review evaluates the recent advances in mitochondrial ROS imaging approaches with emphasis on their proper application and limitations, and highlights the future perspectives in the development of novel fluorescent probes for visualizing all species of ROS.
File Format	HTM / HTML
ISSN	10715762
Issue Number	4
Volume Number	49
e-ISSN	10292470
Journal	Free Radical Research
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Fluorescent Dyes Mitochondria Chemistry Optical Imaging Methods Reactive Oxygen Species Analysis Animals Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry

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