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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Myllynen, Päivi Kummu, Maria Sieppi, Elina |
| Description | Country affiliation: Finland Author Affiliation: Myllynen P ( University of Oulu, Institute of Biomedicine, Department of Pharmacology and Toxicology, PO Box 5000, FIN-90014 Oulu, Finland. paivi.myllynen@oulu.fi) |
| Abstract | IMPORTANCE OF THE FIELD: ABCB1 and ABCG2 are efflux transporters which have a major impact on the pharmacological behavior of numerous drugs. They are expressed, for example, in the intestine, liver, kidney, BBB and placenta. It has become evident that ABCB1 and ABCG2 modify the pharmaco/toxicokinetics in the placenta and fetus and may consequently affect the outcome of pregnancy. AREAS COVERED IN THIS REVIEW: Comprehensive literature searches were done using PubMed (until June 2010) to identify publications on ABCB1 and ABCG2 expression in placenta and fetal tissues in human, mouse, rat, guinea-pig and rabbit. WHAT THE READER WILL GAIN: In this review, we aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species. TAKE HOME MESSAGE: The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good correlation among human, mouse and rat although some specific differences have been reported. However, at this point no detailed comparisons or comparative functional data are available. Detailed knowledge on the expression patterns and functional activity of ABCB1 and ABCG2 transporters placenta and developing embryo/fetus in different species could possibly help the interspecies extrapolation. |
| File Format | HTM / HTML |
| ISSN | 17425255 |
| Issue Number | 11 |
| Volume Number | 6 |
| e-ISSN | 17447607 |
| Journal | Expert Opinion on Drug Metabolism & Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Discipline Pharmacology Atp-binding Cassette Transporters Genetics Gene Expression Neoplasm Proteins P-glycoprotein Animals Female Fetus Metabolism Guinea Pigs Humans Mice P-glycoproteins Pharmaceutical Preparations Placenta Pregnancy Rabbits Rats Species Specificity Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Pharmacology |
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