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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sehgal, Praveen Kumar Srinivasan, Aishwarya |
| Description | Country affiliation: India Author Affiliation: Sehgal PK ( Central Leather Research Institute, Bio-products Laboratory, Adyar, Chennai-600020, India. sehgal_pk@yahoo.co.in) |
| Abstract | Advantages of drug-incorporated collagen particles have been described for the controlled delivery system for therapeutic actions. The attractiveness of collagen lies in its low immunogenicity and high biocompatibility. It is also recognized by the body as a natural constituent rather than a foreign body. Our research and development efforts are focused towards addressing some of the limitations of collagen, like the high viscosity of an aqueous phase, nondissolution in neutral pH buffers, thermal instability (denaturation) and biodegradability, to make it an ideal material for drug delivery with particular reference to microparticles. These limitations could be overcome by making collagen conjugates with other biomaterials or chemically modifying collagen monomer without affecting its triple helical conformation and maintaining its native properties. This article highlights collagen microparticles' present status as a carrier in drug delivery. |
| File Format | HTM / HTML |
| ISSN | 17425247 |
| Issue Number | 7 |
| Volume Number | 6 |
| e-ISSN | 17447593 |
| Journal | Expert Opinion on Drug Delivery |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Discipline Pharmacology Collagen Chemistry Drug Carriers Drug Delivery Systems Animals Drug Stability Humans Hydrogen-ion Concentration Microspheres Protein Conformation Solubility Temperature Viscosity Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
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