NDLI: Neural mechanisms of anger regulation as a function of genetic risk for violence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alia-Klein, Nelly Goldstein, Rita Z. Tomasi, Dardo Woicik, Patricia A. Moeller, Scott J. Williams, Benjamin Craig, Ian W. Telang, Frank Biegon, Anat Wang, Gene-Jack Fowler, Joanna S. Volkow, Nora D.
Description	Country affiliation: United States Author Affiliation: Alia-Klein N ( Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. nellyklein@bnl.gov)
Abstract	Genetic risk may predispose individuals to compromised anger regulation, potentially through modulation of brain responses to emotionally evocative stimuli. Emphatically expressed, the emotional word No can prohibit behavior through conditioning. In a recent functional magnetic resonance imaging study, the authors showed that healthy males attribute negative valence to No while showing a lateral orbitofrontal response that correlated with their self-reported anger control. Here, the authors examined the influence of the monoamine oxidase A (MAOA) gene (low vs. high transcription variants) on brain response to No and in relationship to trait anger reactivity and control. The orbitofrontal response did not differ as a function of the genotype. Instead, carriers of the low-MAOA genotype had reduced left middle frontal gyrus activation to No compared with the high variant. Furthermore, only for carriers of the up low-MAOA genotype, left amygdala and posterior thalamic activation to No increased with anger reactivity. Thus, vulnerability to aggression in carriers of the low-MAOA genotype is supported by decreased middle frontal response to No and the unique amygdala/thalamus association pattern in this group with anger reactivity but not anger control.
File Format	HTM / HTML
ISSN	15283542
e-ISSN	19311516
DOI	10.1037/a0015904
Journal	Emotion
Issue Number	3
Volume Number	9
Language	English
Publisher	American Psychological Association
Publisher Date	2009-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychology Physiology Brain Violence Psychology Amygdala Brain Mapping Emotions Facial Expression Frontal Lobe Genetic Predisposition To Disease Genetics Genotype Monoamine Oxidase Neural Pathways Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Medicine Psychology

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