NDLI: Nichtkleinzellige Lungenkarzinome. Subklassifikation und prädiktive molekulare Markeruntersuchungen in der Zytologie.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Savic, S. Bihl, M. P. Bubendorf, L.
Description	Author Affiliation: Savic S ( Institut für Pathologie, Universitätsspital Basel, Schönbeinstr. 40, 4031, Basel, Schweiz. ssavic@uhbs.ch)
Abstract	The diagnosis and treatment of non-small cell lung cancer (NSCLC) have been revolutionized over the last few years. Requirements for cytopathologists in lung cancer diagnosis have therefore changed. The general diagnostic category of NSLC is no longer sufficient. In addition cytological specimens need to be evaluated for adequacy regarding predictive marker analyses. Accurate NSCLC subtyping with a distinction of adenocarcinoma from squamous cell carcinoma is crucial for treatment decisions as the subtype will decide on the chemotherapy regimen and the choice of predictive marker analyses for targeted treatment. In the majority of cases, the subtype can be diagnosed by morphology alone. Cytology is equally well suited as biopsy specimens for the assessment of molecular predictive markers. The best results are achieved when both cytology and biopsy specimens are compared to choose the most appropriate specimen for morphological subtyping and molecular testing. In this paper, we discuss special issues of NSCLC subtyping and currently recommended predictive molecular marker analyses.
File Format	HTM / HTML
ISSN	01728113
Issue Number	4
Volume Number	33
e-ISSN	14321963
Journal	Der Pathologe
Language	German
Publisher	Springer
Publisher Date	2012-07-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pathology Carcinoma, Non-small-cell Lung Pathology Cell Biology Genetic Markers Genetics Lung Neoplasms Adenocarcinoma Classification Drug Therapy Algorithms Antineoplastic Agents Therapeutic Use Biopsy Carcinoma, Squamous Cell Dna Mutational Analysis Humans Immunohistochemistry Methods Lung Neoplasm Staging Oncogene Proteins, Fusion Predictive Value Of Tests Prognosis Proto-oncogene Proteins Proto-oncogene Proteins P21(ras) Receptor, Epidermal Growth Factor Treatment Outcome Ras Proteins Journal Article Review
Alternative Title	Non-small cell lung cancer. Subtyping and predictive molecular marker investigations in cytology
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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