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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Perona, Rosario López-Ayllón, Blanca D. de Castro Carpeño, Javier Belda-Iniesta, Cristóbal |
| Description | Country affiliation: Spain Author Affiliation: Perona R ( Instituto de Investigaciones Biomédicas CSIC/UAM, CIBER de Enfermedades Raras, IdiPAZ, Madrid, Spain. rperona@iib.uam.es) |
| Abstract | The cancer stem cell (CSC) theory is currently a very important field in cancer research. This theory states that tumours are organised in a hierarchical manner with a subpopulation of limited number called CSCs with the ability to self-renew and undergo asymmetrical divisions, giving rise to a differentiated progeny that represents most of the tumour populations. CSCs are metastatic and chemoresistant, two features that very likely contribute to the poor response of locally advanced lung cancer. CSCs have been identified in non-small-cell lung cancer cell lines as well as those from patient primary samples. A correlation has been found in terms of chemoresistance and bad prognosis in patient-derived samples enriched with CSCs, indicating that these cells are an important target for future therapy combinations. Therefore, understanding the biology and exploring cell markers and signalling pathways specific for CSCs of lung cancer may help in achieving progress in the treatment of the disease. |
| File Format | HTM / HTML |
| ISSN | 1699048X |
| Issue Number | 5 |
| Volume Number | 13 |
| e-ISSN | 16993055 |
| Journal | Clinical and Translational Oncology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2011-05-01 |
| Publisher Place | Italy |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Carcinoma, Non-small-cell Lung Drug Therapy Pathology Drug Resistance, Neoplasm Lung Neoplasms Neoplastic Stem Cells Cytology Aldehyde Dehydrogenase Metabolism Antigens, Cd Biosynthesis Antigens, Cd34 Antigens, Cd44 Cell Differentiation Glycoproteins Humans Medical Oncology Methods Neoplasm Metastasis Peptides Signal Transduction Transcription Factors Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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