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Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients: Insights From Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cooper, Lauren B. Mentz, Robert J. Sun, Jie-Lena Schulte, Phillip J. Fleg, Jerome L. Cooper, Lawton S. Piña, Ileana L. Leifer, Eric S. Kraus, William E. Whellan, David J. Keteyian, Steven J. O'Connor, Christopher M.
Description	Author Affiliation: Cooper LB ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Mentz RJ ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Sun JL ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Schulte PJ ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Fleg JL ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Cooper LS ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Piña IL ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Leifer ES ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Kraus WE ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Whellan DJ ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); Keteyian SJ ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC); O'Connor CM ( From the Duke Clinical Research Institute (L.B.C., R.J.M., J.-L.S., P.J.S., C.M.O'C.), and Department of Medicine (L.B.C., R.J.M., W.E.K., C.M.O'C.), Duke University School of Medicine, Durham, NC)
Abstract	BACKGROUND: Psychosocial factors may influence adherence with exercise training for heart failure (HF) patients. We aimed to describe the association between social support and barriers to participation with exercise adherence and clinical outcomes. METHODS AND RESULTS: Of patients enrolled in Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION), 2279 (97.8%) completed surveys to assess social support and barriers to exercise, resulting in the perceived social support score (PSSS) and barriers to exercise score (BTES). Higher PSSS indicated higher levels of social support, whereas higher BTES indicated more barriers to exercise. Exercise time at 3 and 12 months correlated with PSSS (r= 0.09 and r= 0.13, respectively) and BTES (r=-0.11 and r=-0.12, respectively), with higher exercise time associated with higher PSSS and lower BTES (All P<0.005). For cardiovascular death or HF hospitalization, there was a significant interaction between the randomization group and BTES (P=0.035), which corresponded to a borderline association between increasing BTES and cardiovascular death or HF hospitalization in the exercise group (hazard ratio 1.25, 95% confidence interval 0.99, 1.59), but no association in the usual care group (hazard ratio 0.83, 95% confidence interval 0.66, 1.06). CONCLUSIONS: Poor social support and high barriers to exercise were associated with lower exercise time. PSSS did not impact the effect of exercise training on outcomes. However, for cardiovascular death or HF hospitalization, exercise training had a greater impact on patients with lower BTES. Given that exercise training improves outcomes in HF patients, assessment of perceived barriers may facilitate individualized approaches to implement exercise training therapy in clinical practice. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00047437.
File Format	HTM / HTML
ISSN	19413289
e-ISSN	19413297
Journal	Circulation: Heart Failure
Issue Number	6
Volume Number	8
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2015-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Heart Failure Psychology Therapy Patient Compliance Exercise Tolerance Mortality Hospitalization Quality Of Life Stroke Volume Multicenter Study Randomized Controlled Trial Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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