NDLI: Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats.

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Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats.

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Year: 2011 Volume: 89 Issue: 1

Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lautt, W. Wayne Schafer, Joshua Macedo, M. Paula Legare, Dallas J.
Description	Country affiliation: Canada Author Affiliation: Lautt WW ( Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba, Canada. wlautt@cc.umanitoba.ca)
Abstract	Meal-induced insulin sensitization (MIS) is explained by the HISS (hepatic insulin sensitizing substance) hypothesis. In the presence of two 'feeding signals,' a pulse of insulin results in the release of HISS from the liver. HISS acts selectively on skeletal muscle and doubles the response to insulin. HISS is not released in the fasted state or in the sucrose-supplemented diabetes model. We tested the hypothesis that provision of both feeding signals allows insulin to cause HISS release in both the normal fasted and the diabetic model. The dynamic response to insulin (50 mU/kg over 5 min) was quantified using the rapid insulin sensitivity test (RIST). Gastric injection of a liquid test meal or i.v. administration of N-acetylcysteine in 24 h fasted rats raised hepatic glutathione to a similar degree (by 46%-47%). Hepatic denervation in fed rats eliminated the parasympathetic signal and eliminated MIS, and bethanechol completely restored MIS. Both compounds administered together allowed insulin to stimulate HISS release in 24 h fasted rats and in a diabetic model (9-week, 35% liquid sucrose supplement). Neither was effective alone. Both 'feeding signals' are necessary and sufficient for insulin to stimulate HISS release.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	2
Volume Number	89
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2011-02-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Acetylcysteine Pharmacology Bethanechol Diabetes Mellitus, Experimental Metabolism Feeding Behavior Drug Effects Physiology Insulin Resistance Animals Biomimetic Materials Fasting Glutathione Insulin Liver Muscarinic Agonists Muscle, Skeletal Parasympathetic Nervous System Rats, Sprague-dawley Sucrose Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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