NDLI: Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats.

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Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats.

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Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hussein, Abd El-Aziz M. Abbas, Amr M. El Wakil, Gehan A. Elsamanoudy, Ayman Z. El Aziz, Azza Abd
Description	Country affiliation: Egypt Author Affiliation: Hussein Ael-A ( Department of Medical Physiology, Faculty of Medicine, Mansoura University, Egypt. zizomenna@yahoo.com)
Abstract	Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 µg/L) for 8 weeks. Serum thyroxine (T(4)), triiodothyronine (T(3)), thyroid-stimulating hormone (TSH), thyroid antioxidants (catalase, superoxide dismutase enzymes, and total antioxidants), and lipid peroxide (malondialdehyde; MDA) were measured. Reverse transcription - PCR gene expression for thyroidal Na(+)/I(-) symporter (NIS), D1 deiodinase, and thyroid peroxidase (TPO) were performed. Thiocyanate significantly decreased thyroid hormones (T(3), T(4)), increased lipid peroxides and antioxidants, and increased gene expression of NIS, D1 deiodinase, and TPO. Excess iodine intake in hypothyroid rats increased T3 and T4. Also, high iodine intake by hypothyroid rats significantly decreased NIS, D1 deiodinase, and TPO genes expression. Excess iodine significantly increased MDA and antioxidants in euthyroid and hypothyroid rats. In conclusion, thiocyanate-hypothyroidism increases gene expression of NIS, TPO, and TPO and induces oxidative stress. High iodine intake decreases NIS and D1 deiodinase gene expression in hypothyroid rats. Moreover, excess iodine increase thyroid hormones, lipid peroxides, and antioxidants in hypothyroid rats.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	5
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-05-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Hypothyroidism Metabolism Iodine Administration & Dosage Oxidative Stress Drug Effects Thyroid Gland Animals Antioxidants Catalase Gene Expression Blood Genetics Iodide Peroxidase Toxicity Urine Lipid Peroxides Malondialdehyde Rats, Sprague-dawley Superoxide Dismutase Symporters Thiocyanates Thyrotropin Thyroxine Triiodothyronine
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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