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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Zi-ping Huo, Jian-min Sang, Yu-lan Kang, Jian Li, Xue |
| Description | Author Affiliation: Xu ZP ( Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China.) |
| Abstract | We investigated the effects of arsenic trioxide (As(2)O(3)) as a possible approach for preventing airway remodeling in a murine model of bronchial asthma induced by ovalbumin (OVA) challenge. Forty Balb/c mice were randomly assigned to 1 of 4 groups (10 mice/group) as follows: controls (challenged with sterile saline inhalation only); OVA-challenged, no treatment; OVA-challenged, treated with dexamethasone; and OVA-challenged, treated with As(2)O(3). All mice were sensitized by intraperitoneal injection with 10% OVA at 2 weeks prior to saline or OVA inhalation challenge. Challenges were for 8 weeks. After OVA challenge, typical asthma-like morphology changes in the bronchi and lung tissues were observed by hematoxylin-eosin staining and pulmonary function indices were reduced compared with controls. Changes in pulmonary indices and lung tissues were similar in the dexamethasone and As(2)O(3) groups and were in between those of the untreated and control groups. Compared with the untreated group, transforming growth factor ß1, vascular endothelial growth factor, and matrix metalloproteinase-9 protein levels and mRNA expression were decreased in lung tissues of the dexamethasone and As(2)O(3) groups. Our results suggest that steroids and As(2)O(3) can inhibit airway remodeling in chronic asthma by mechanisms related to inhibiting the expression of the 3 aforementioned mediators. |
| File Format | HTM / HTML |
| ISSN | 00084212 |
| e-ISSN | 12057541 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Issue Number | 12 |
| Volume Number | 90 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2012-12-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Airway Remodeling Drug Effects Arsenicals Pharmacology Asthma Drug Therapy Bronchi Lung Oxides Genetics Animals Metabolism Pathology Dexamethasone Matrix Metalloproteinase 9 Mice Mice, Inbred Balb C Ovalbumin Random Allocation Respiratory Function Tests Transforming Growth Factor Beta1 Vascular Endothelial Growth Factor A |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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