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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Haley, Cecily L. Kruczek, Cassandra Qaisar, Uzma Colmer-Hamood, Jane A. Hamood, Abdul N. |
| Description | Country affiliation: United States Author Affiliation: Haley CL ( Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street STOP 6591, Lubbock, TX 79430, USA.) |
| Abstract | In Pseudomonas aeruginosa, type IV pili (TFP)-dependent twitching motility is required for development of surface-attached biofilm (SABF), yet excessive twitching motility is detrimental once SABF is established. In this study, we show that mucin significantly enhanced twitching motility and decreased SABF formation in strain PAO1 and other P. aeruginosa strains in a concentration-dependent manner. Mucin also disrupted partially established SABF. Our analyses revealed that mucin increased the amount of surface pilin and enhanced transcription of the pilin structural gene pilA. Mucin failed to enhance twitching motility in P. aeruginosa mutants defective in genes within the pilin biogenesis operons pilGHI/pilJK-chpA-E. Furthermore, mucin did not enhance twitching motility nor reduce biofilm development by chelating iron. We also examined the role of the virulence factor regulator Vfr in the effect of mucin. In the presence or absence of mucin, PAOΔvfr produced a significantly reduced SABF. However, mucin partially complemented the twitching motility defect of PAOΔvfr. These results suggest that mucin interferes with SABF formation at specific concentrations by enhancing TFP synthesis and twitching motility, that this effect, which is iron-independent, requires functional Vfr, and only part of the Vfr-dependent effect of mucin on SABF development occurs through twitching motility. |
| File Format | HTM / HTML |
| ISSN | 00084166 |
| e-ISSN | 14803275 |
| DOI | 10.1139/cjm-2013-0570 |
| Journal | Canadian Journal of Microbiology |
| Issue Number | 3 |
| Volume Number | 60 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2014-03-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Microbiology Biofilms Growth & Development Fimbriae, Bacterial Physiology Mucins Pseudomonas Aeruginosa Bacterial Proteins Chemistry Genetics Fimbriae Proteins Metabolism Movement Pathogenicity Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology Immunology Microbiology Applied Microbiology and Biotechnology |
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