Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Han, Liping Zhong, Yun Huang, Binlu Han, Limei Pan, Lina Xu, Xin Wang, Xiuli Huang, Baiqu Lu, Jun |
| Description | Author Affiliation: Han L ( The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, PR China.) |
| Abstract | Sodium butyrate (NaBu) has been shown to induce erythroid cell differentiation. In this study, we investigated the mechanisms involved in NaBu-induced activation of erythroid-specific 5-aminolevulinate synthase gene (ALAS2). We showed that NaBu upregulated ALAS2 gene transcription in different cell lineages. By using site-directed mutagenesis of putative responsive elements at ALAS2 promoter and reporter gene analysis, we identified that the Sp1 binding sites within the ALAS2 promoter were responsive to NaBu stimulation. Results from the chromatin immunoprecipitation (ChIP) assays indicated that upon the NaBu stimulation, binding of Sp1 protein to ALAS2 promoter increased significantly, with concurrent increases in acetylation level of histone H3 and dimethylation level of H3-Lysine4 at ALAS2 promoter. Also, our data suggested that HDAC1 may be a target enzyme of NaBu action. |
| File Format | HTM / HTML |
| ISSN | 10799796 |
| Issue Number | 2 |
| Volume Number | 41 |
| e-ISSN | 10960961 |
| Journal | Blood Cells, Molecules, and Diseases |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Hematology 5-aminolevulinate Synthetase Genetics Enhancer Elements, Genetic Drug Effects Erythroid Cells Enzymology Gene Expression Regulation, Enzymologic Sp1 Transcription Factor Acetylation Butyrates Pharmacology Cell Line, Tumor Histone Deacetylase 1 Histone Deacetylases Metabolism Histones Humans Methylation Mutagenesis, Site-directed Promoter Regions, Genetic Protein Binding Up-regulation Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Hematology Molecular Biology Molecular Medicine |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|