NDLI: Congenital cardiovascular malformations and the fetal circulation.

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Year: 2010 Volume: 95 Issue: 1

Year: 2009 Volume: 94

Year: 2008 Volume: 93

Year: 2007 Volume: 92

Congenital cardiovascular malformations and the fetal circulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rudolph, A. M.
Description	Country affiliation: United States Author Affiliation: Rudolph AM ( University of California, San Francisco, Box 0544, University of California, San Francisco, CA 94143, USA. Abraham.Rudolph@ucsf.edu)
Abstract	After birth, gas exchange is achieved in the lung, whereas prenatally it occurs in the placenta. This is associated with differences in blood flow patterns in the fetus as compared with the postnatal circulation. Congenital cardiovascular malformations are associated with haemodynamic changes in the fetus, which differ from those occurring postnatally. Obstruction to cardiac outflow may alter myocardial development, resulting in progressive ventricular hypoplasia. Alteration of oxygen content may profoundly influence pulmonary vascular and ductus arteriosus responses. Interference in blood flow and oxygen content may affect cerebral development as a result of inadequate oxygen or energy substrate supply. The circulatory effects may be gestational dependent, related to maturation of vascular responses in different organs. These prenatal influences of congenital cardiac defects may severely affect immediate, as well as longterm, postnatal prognosis and survival. This has stimulated the development of techniques for palliation of disturbed circulation during fetal life.
File Format	HTM / HTML
ISSN	13592998
Issue Number	2
Volume Number	95
e-ISSN	14682052
Journal	Archives of Disease in Childhood - Fetal and Neonatal Edition
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2010-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Discipline Perinatology Cardiovascular Abnormalities Embryology Fetus Blood Supply Aorta Blood Pressure Physiology Cardiac Output Ductus Arteriosus Fetal Blood Humans Oxygen Blood Pulmonary Circulation Vascular Resistance Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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