NDLI: Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Viswanathan, Rajlakshmi Singh, Arun Kumarendu Basu, Sulagna Chatterjee, Suparna Sardar, Syamal Isaacs, David
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Viswanathan R ( Department of Neonatology, IPGMER, Kolkata, India. docrumic@yahoo.co.in)
Abstract	OBJECTIVE: To study the organisms causing early and late onset neonatal sepsis, with special reference to multi-drug resistant gram negative bacilli, at two neonatal units (one urban, one rural) in India. METHODS: Prospective surveillance study. RESULTS: There were 159 episodes of sepsis (81 urban and 77 rural) affecting 158 babies. Gram negative bacilli caused 117 infections (68%) and predominated at both centres in both early and late sepsis. Klebsiella pneumoniae was the commonest organism, causing 61 infections (38.3%). In early sepsis (0-2 days), non-fermenting gram negative bacilli caused 42.1% of infections at the urban centre; there were no cases of early Group B Streptococcus sepsis. Late onset sepsis was mainly caused by gram negative bacilli at both centres. Multi-drug resistance of over 80% of early-onset gram negative organisms to ampicillin, third generation cephalosporins and gentamicin indicates that these multi-resistant organisms are almost certainly circulating widely in the community. The overall mortality from early sepsis was 27.3% (9 of 33) and from late sepsis was 26.2% (33 of 126). Gram negative bacilli caused all deaths from early sepsis and 87.5% of deaths from late sepsis. CONCLUSION: This study shows that multi-drug resistant gram negative bacilli are a major cause of early and late neonatal sepsis in India and are almost certainly widespread in the community.
File Format	HTM / HTML
ISSN	13592998
Issue Number	3
Volume Number	97
e-ISSN	14682052
Journal	Archives of Disease in Childhood - Fetal and Neonatal Edition
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2012-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Discipline Perinatology Drug Resistance, Multiple, Bacterial Gram-negative Bacterial Infections Epidemiology Sepsis Age Factors Anti-bacterial Agents Therapeutic Use Birth Weight Gestational Age Gram-negative Bacteria Drug Effects Drug Therapy Microbiology Humans Incidence India Infant, Newborn Intensive Care Units, Neonatal Prospective Studies Rural Health Statistics & Numerical Data Urban Health Journal Article Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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