NDLI: The impact of adenosine pharmacologic stress combined with low-level exercise in patients undergoing myocardial perfusion imaging (BIWAKO adenosine-Ex trial).

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The impact of adenosine pharmacologic stress combined with low-level exercise in patients undergoing myocardial perfusion imaging (BIWAKO adenosine-Ex trial).

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The impact of adenosine pharmacologic stress combined with low-level exercise in patients undergoing myocardial perfusion imaging (BIWAKO adenosine-Ex trial).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Monzen, Hajime Hara, Masatake Hirata, Makoto Suzuki, Takatoshi Ogasawara, Makoto Higuchi, Hirokazu Matsuoka, Tomohiro Kobayashi, Hisato Yuki, Rumio Hirose, Kunihiko
Description	Country affiliation: Japan Author Affiliation: Monzen H ( Department of Radiology, Otsu Red Cross Hospital, 1-35 Nagara, Otsu, Shiga, 520-8511, Japan. hmrky77@u01.gate01.com)
Abstract	BACKGROUND: The combination of adenosine infusion with low-level exercise has become a common approach for inducing stress during stress myocardial perfusion imaging (MPI). We investigated stress MPI performed by combined low-level exercise and adenosine infusion. This combined protocol can decrease adverse reactions and reduce the effect of scattered rays from the liver. METHODS AND RESULTS: Subjects were clinically referred for a 53-min rest-stress Tc-99m Sestamibi MPI procedure using BIWAKO PROTOCOL. Ninety-eight patients (44.5%) underwent adenosine infusion with ergometer exercise testing and 122 patients (55.5%) underwent adenosine infusion without exercise testing. We evaluated the liver/heart (L/H) uptake ratio, background activity in the upper mediastinum, and adverse reactions. RESULTS: The L/H ratio and background activity were lower in the adenosine-exercise group than in the adenosine-non-exercise group (1.8 ± 0.54 vs. 2.1 ± 0.62, P < 0.0056; 43.1 ± 12.2 vs. 61.5 ± 15.4, P < 0.0001). The adenosine-exercise group had fewer adverse reactions than the adenosine-non-exercise group (11.2 vs. 19.7%). All of the adverse reactions were minor, with the exception of severe back pain in one case. The incidence of adverse reactions in our study was lower than that in previous studies for unknown reason. CONCLUSION: Adenosine infusion in combination with low-level exercise seems to result in higher-quality images and fewer adverse reactions than adenosine infusion without exercise. The combined protocol decreases adverse reactions and improves the quality of myocardial perfusion images by decreasing background activity.
File Format	HTM / HTML
ISSN	09147187
Issue Number	5
Volume Number	25
e-ISSN	18646433
Journal	Annals of Nuclear Medicine
Language	English
Publisher	Springer
Publisher Date	2011-06-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nuclear Medicine Adenosine Pharmacology Exercise Myocardial Perfusion Imaging Methods Stress, Physiological Drug Effects Adverse Effects Aged Female Heart Humans Liver Metabolism Male Mediastinum Myocardium Quality Control Safety Clinical Trial Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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