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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Leyuan Zolotarskaya, Olga Yu Yeudall, W. Andrew Yang, Hu |
| Description | Country affiliation: United States Author Affiliation: Xu L ( Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, 23284, USA.) |
| Abstract | Immobilizing highly branched polyamidoamine (PAMAM) dendrimers to the cell surface represents an innovative method of enhancing cell surface loading capacity to deliver therapeutic and imaging agents. In this work, hybridized immune cells, that is, macrophage RAW264.7 (RAW), with PAMAM dendrimer G4.0 (DEN) on the basis of bioorthogonal chemistry are clicked. Efficient and selective cell surface immobilization of dendrimers is confirmed by confocal microscopy. Viability and motility of RAW-DEN hybrids remain the same as untreated RAW cells according to WST-1 assay and wound closure assay. Furthermore, Western blot analysis reveals that there are no significant alterations in the expression levels of signaling molecules AKT, p38, and NFκB (p65) and their corresponding activated (phosphorylated) forms in RAW cells treated with azido sugar and dendrimer, indicating that the hybridization process neither induced cell stress response nor altered normal signaling pathways. Taken together, this work shows the feasibility of applying bioorthogonal chemistry to create cell-nanoparticle hybrids and demonstrates the noninvasiveness of this cell surface engineering approach. |
| File Format | HTM / HTML |
| ISSN | 21922640 |
| e-ISSN | 21922659 |
| DOI | 10.1002/adhm.201300515 |
| Journal | Advanced Healthcare Materials |
| Issue Number | 9 |
| Volume Number | 3 |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2014-09-01 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Discipline Biomedical Engineering Click Chemistry Dendrimers Chemistry Macrophages Cytology Polyamines Animals Cell Movement Drug Effects Cell Survival Toxicity Metabolism Materials Testing Mice Nanoparticles Signal Transduction Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering Pharmaceutical Science |
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