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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gao, Wei Meng, Tingting Shi, Nianqiu Zhuang, Hongmeng Yang, Zhenzhen Qi, Xianrong |
| Description | Author Affiliation: Gao W ( State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, P. R China.) |
| Abstract | Poor recognition and penetration of chemotherapeutic agents in solid tumors have been recognized as one of the major challenges limiting the efficacy of cancer therapies. Folic acid and tumor microenvironment-sensitive polypeptide (TMSP) co-modified lipid-nanocarrier (F/TMSP-NLC) are successfully formulated in response to the overexpression of folate receptor (FR) and the upregulation of matrix metalloproteinase-2 (MMP-2) in tumor microenvironment. The F/TMSP-NLC accumulates in tumor via the enhanced permeability and retention (EPR) effect, and folate moiety binds selectively to the FR once it reaches the tumor. In addition, cell-penetrating peptide (CPP)-penetrating activity is initiated by MMP-2 protease-oversecretion tumor. The specificity and efficacy of the co-modified nanocarriers to tumor are investigated in KB, HT-1080 and A549 cells in vitro. Multivalent interactions induce the enhancement of cancer cell recognition and internalization, which subsequently result in cancer cell apoptosis or death. The F/TMSP-NLC shows long-circulation effect, high accumulation in tumor, strong tumor inhibition, increased apoptotic indices, and negligible toxicity in vivo. In conclusion, the present nanocarrier modified with both TMSP and folic acid is a potential drug delivery system for tumor cell recognition and therapy, implying that using more than one target from the pool of tumor-stroma interactions is profoundly beneficial to therapeutic approaches. |
| File Format | HTM / HTML |
| ISSN | 21922640 |
| Issue Number | 5 |
| Volume Number | 4 |
| e-ISSN | 21922659 |
| Journal | Advanced Healthcare Materials |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-04-02 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical Engineering Antineoplastic Agents Pharmacokinetics Drug Carriers Lipids Nanostructures Chemistry Animals Pharmacology Toxicity Apoptosis Drug Effects Cell Cycle Cell Line, Tumor Cell-penetrating Peptides Folic Acid Humans Male Mice Mice, Inbred Balb C Rats Rats, Sprague-dawley Tissue Distribution Tumor Microenvironment Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering Pharmaceutical Science |
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