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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Qian Shi, Changcan Zhang, Wencheng Behl, Marc Lendlein, Andreas Feng, Yakai |
| Description | Country affiliation: China Author Affiliation: Li Q ( School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.); Shi C ( School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.); Zhang W ( Department of Physiology and Pathophysiology, Logistics University of Chinese People's Armed Police Force, Tianjin, 300162, China.); Behl M ( Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin, 300072, China.); Lendlein A ( Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513, Teltow, Germany.); Feng Y ( Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin, 300072, China.) |
| Abstract | Amphiphilic block copolymers containing biodegradable hydrophobic segments of depsipeptide based copolymers have been synthesized and explored as gene carriers for enhancing proliferation of endothelial cells in vitro. These polymers form nanoparticles (NPs) with positive charges on their surface, which could condense recombinant plasmids of enhanced green fluorescent protein plasmid and ZNF580 gene (pEGFP-ZNF580) and protect them against DNase I. ZNF580 gene is efficiently transported into EA.hy926 cells to promote their proliferation, whereby the transfection efficiency of NPs/pEGFP-ZNF580 is approximately similar to that of Lipofectamine 2000. These results indicate that the NPs might have potential as a carrier for pEGFP-ZNF580, which could support endothelialization of cardiovascular implants. |
| File Format | HTM / HTML |
| ISSN | 21922640 |
| Issue Number | 8 |
| Volume Number | 4 |
| e-ISSN | 21922659 |
| Journal | Advanced Healthcare Materials |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-06-03 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical Engineering Cell Proliferation Endothelial Cells Metabolism Genetic Vectors Nanoparticles Chemistry Cell Line Cell Survival Deoxyribonuclease I Drug Carriers Gene Transfer Techniques Green Fluorescent Proteins Genetics Humans Hydrophobic And Hydrophilic Interactions Lipids Magnetic Resonance Spectroscopy Particle Size Plasmids Polyethyleneimine Polymers Spectroscopy, Fourier Transform Infrared Transcription Factors Transfection Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering Pharmaceutical Science |
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